Addiction

Glutamate plays a central role in the development and maintenance of addictive behaviors in all addictions as it alters reward signaling. Normalization of glutamate signaling should make a significant improvement in addictive behavior and underlying addiction. This is not a comprehensive list, simply some articles I have found along the way. “Traditionally, addiction research in neuroscience has focused on mechanisms involving dopamine and endogenous opioids. More recently, it has been realized that glutamate also plays a central role in processes underlying the development and maintenance of addiction. These processes include reinforcement, sensitization, habit learning and reinforcement [...]