microglia

Lowering Glutamate | Luteolin Flavonoid

Lowering Glutamate | Luteolin Flavonoid

Luteolin- A type of flavonoid found in celery, chamomile, carrots, celery, parsley, thyme, oregano, sage, basil, peppermint, artichoke and spinach is known to reduce brain and systematic inflammation by CALMING MICROGLIAL CELLS and therefore lower glutamate and cytokine levels (microglia are activated as a first step in immune response and they signal additional glutamate). Mixing these food sources with coconut oil or olive oil will help increase absorption. It is also a strong inhibitor of mast cells and helps autoimmune disorders with the reduction of immune cells. Luteolin has also been shown to stimulate brain repair, reduce exitotoxicity (from [...]

Lowering Glutamate | Luteolin Flavonoidandistowe2024-08-24T18:57:01-04:00

Lowering Glutamate | Licorice Root (Glycyrrhizin)

Lowering Glutamate | Licorice Root (Glycyrrhizin)

Licorice Root (Glycyrrhizin) high in Carbenoxolone – inhibits glutamate release from microglia! “Liquiritigenin effectively reduced glutamate-induced early apoptosis through inhibition of Ca(2+) influx, intracellular reactive oxygen species (ROS) production, and lipid peroxidation.” https://www.ncbi.nlm.nih.gov/pubmed/24012889 “These observations suggest that glycyrrhizic acid may be of therapeutic value for the prevention of cerebral damage elicited by the glutamate.” http://europepmc.org/abstract/med/16952351 Thus, blockade of glutamate release from activated microglia with CBX or DON may be an effective therapeutic strategy against neurodegeneration in MS. https://www.ncbi.nlm.nih.gov/pubmed/19212100

Lowering Glutamate | Licorice Root (Glycyrrhizin)andistowe2024-08-24T18:54:50-04:00

Lowering Glutamate | Ginseng

Lowering Glutamate | Ginseng

Ginseng– inhibits inflammation caused by microglial/immune activation and therefore lower glutamate and cytokine levels (microglia are activated as a first step in immune response and they signal additional glutamate/cytokines/etc). “Ginseng extracts also inhibit immunoexcitotoxic activation of microglia, an important factor in preventing the destructive process of Alzheimer’s disease. In fact, components in American ginseng, Korean red ginseng, and Panax ginseng all inhibit inflammation caused by microglial activation. Regulation of microglial activity is critically important in brain protection because these specialized immune cells can either be beneficial or quite harmful, depending on what state they are in. The protective activation mode stimulates [...]

Lowering Glutamate | Ginsengandistowe2024-08-24T18:44:36-04:00

Why Are More Males Affected With Autism?

Why Are More Males Affected With Autism?

While there are many theories on this, I found the glutamate and immune activation connection to be the most interesting. Often you will hear children with autism have experienced some sort of trauma (prematurity, stroke, etc.) or substantial changes to immune function, leading to immune activation (vaccines, illness, and it is now linked that mothers immune activation can trigger immune activation within the fetus, and so on) that parents believe may have triggered or caused their autism. Both trauma and immune activation cause an increase in glutamate. “It was initially thought that autistic children had fewer glutamate [...]

Why Are More Males Affected With Autism?andistowe2019-04-07T21:38:39-04:00