Lowering Glutamate | Alpha Lipoic Acid

Alpha Lipoic Acid–  (found in low amounts in spinach, broccoli, yams, etc) ALA is most commonly known a chelating supplement as part of the Andy Cutler Protocol, it is also antioxidant that helps glutamate transport proteins, which aid in the removal of excess extracellular glutamate “Another particularly destructive product is 4-hydroxynonenal (4-HNE), an aldehydic lipid peroxidation product found in abundant supply in cases of neurodegeneration. Interestingly, peroxylnitrite and 4-HNE are found in the same neurons. This lipid peroxidation product has been shown to be especially destructive of synaptic connections and mitochondrial enzymes and can significantly inhibit [...]

Lowering Glutamate | Alpha Lipoic Acid2024-08-24T18:22:42-04:00

Lowering Glutamate | Ashwagandha

Ashwaganda (Withania somnifera)– Protects against glutamate.  Though most commonly known for aiding in adrenal fatigue, this mild herb is protective against glutamate.  We've been able to source it here and most commonly add it to our teas. Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. “ASH-WEX pre-treatment inhibited glutamate-induced cell death and was able to revert glutamate-induced changes in HSP70 to a large extent. Furthermore, the analysis on the neuronal plasticity marker NCAM (Neural cell adhesion molecule) and its polysialylated form, PSA-NCAM revealed that ASH-WEX has therapeutic potential for prevention [...]

Lowering Glutamate | Ashwagandha2024-08-24T18:23:59-04:00

Lowering Glutamate | Acorus Gramineus (Calamus Root aka Sweet Flag)

Acorus Gramineus (Calamus Root aka Sweet Flag) essential oil has shown to inhibit NMDA (glutamate) receptor activity, increase GABA and lower glutamate upon inhalation. We have been able to source this, here.  I will occasionally add this to our diffuser to help calm any crazy days. “These results demonstrated that EO extracted from AGR exhibited neuroprotective effects on cultured cortical neurons through the blockade of NMDA receptor activity, and that the glycine binding site appeared not to be the major site of action. ” http://www.sciencedirect.com/science/article/pii/S0024320501009444   “Furthermore, inhalation impressively inhibited the activity of gamma-aminobutyric acid (GABA) transaminase, [...]

Lowering Glutamate | Acorus Gramineus (Calamus Root aka Sweet Flag)2024-08-24T18:22:02-04:00
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