Apigenin flavonoid- Found in chamomile, parsley, celery, thyme, lemon balm, cloves, etc.) After years of homeopathy, we discovered that the best remedy during a “flare” or times that we may be a little off, was a low dose of the homeopathic remedy, chamomilla. So I decided to do a little research and of course discovered that it inhibits glutamate because of its high concentration of the flavonoid, apigenin.
- “The flavonoid inhibited also peak amplitude and frequency of spontaneous postsynaptic excitatory currents (sEPSCs). Finally, apigenin is neuroprotective against glutamate-induced neurotoxicity in cerebellar and cortical neurons in culture. Our data reveal the antagonistic effect of apigenin on GABA and NMDA channels.” https://www.ncbi.nlm.nih.gov/pubmed/15464088
- “On the basis of these results, we suggested that apigenin exerts its presynaptic inhibition probably by reducing Ca(2+) entry mediated by the Cav2.2 (N-type) and Cav2.1 (P/Q-type) channels, thereby inhibiting glutamate release from the rat hippocampal nerve terminals.” Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus https://www.ncbi.nlm.nih.gov/pubmed/26007643
- “These data together suggest that apigenin inhibits glutamate-induced calcium signaling in cultured rat hippocampal neurons.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817533/
- “An animal model for the study of Chamomilla in stress and depression: pilot study” https://www.researchgate.net/publication/51430823_An_animal_model_for_the_study_of_Chamomilla_in_stress_and_depression_pilot_study
Why Is This Important?
Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters, dopamine, serotonin and GABA are great examples. When glutamate is in excess it is extremely toxic to the brain and nervous system. It can become so excitatory, it is considered a excitotoxin, which means that it overstimulates brain cells to the point of killing them or damaging them enough to cause severe mitochondrial dysfunction (associated with low muscle tone) and neurological inflammation. Excess glutamate is believed to be involved in a variety of neurological and neurodegenerative disorders including autism, obsessive compulsive disorders, hyperactivity disorders, complex motor stereotypes, tics, insomnia, anxiety disorders, seizures, sensory processing disorder, addiction, depression, chronic fatigue, PANS, PANDAS, Alzheimers, and so on. Excess glutamate also impairs methylation and depletes glutathione levels, which are vital for detoxification, controlling inflammation and gut health. Working to lower glutamate/inflammation and balance GABA, is key to improving overall health.
Obviously diet (REID) is one of the most important, if not, the most important step in lowering glutamate. However, this natural option may prove beneficial in helping when experiencing a peak of symptoms related to high glutamate and neurological inflammation, i.e. following consumption of a high glutamate food, trauma or a “flare” from PANS (pediatric autoimmune neuropsychiatric disorder) or PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections). Additionally, working to lower inflammation/glutamate by treating underlying sources inflammation (metals, microbial imbalances, parasites, microglial activation, poor detoxification pathways, various toxins, etc.) will also be hugely beneficial. We’ve personally found homeopathy to be great for this.
I do not have personal experience with all options mentioned in the “Lowering Glutamate” page, nor would I recommend all of them (especially the pharmaceutical options). You will want to read the comments as some of the items used to temporarily lower glutamate, can actual work to increase glutamate/glutamate sensitivity over time.
The information shared within this blog has been gathered by a mother, not a physician, and should not act as medical advice. Under no circumstances shall I, or any contributors and affiliates of the blog, be responsible for damages arising from use of the blog.