Beta-caryophyllene (found in Cannabis, Copaiba Essential Oil, etc) and CBD- Protects against glutamate.
- “β-Caryophyllene Protects The C6 Glioma Cells Against Glutamate-Induced Excitotoxicity Through The Nrf2 Pathway.. Available from: https://www.researchgate.net/publication/265393128_b Caryophyllene_Protects_The_C6_Glioma_Cells_Against_Glutamate-Induced_Excitotoxicity_Through_The_Nrf2_Pathway [accessed Oct 26 2017].” https://www.researchgate.net/publication/265393128_b-Caryophyllene_Protects_The_C6_Glioma_Cells_Against_Glutamate-Induced_Excitotoxicity_Through_The_Nrf2_Pathway
“Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271072/
- Cannabis “Limited research carried out in humans tends to support the evidence that chronic cannabis use reduces levels of glutamate-derived metabolites in both cortical and subcortical brain areas. Research in animals tends to consistently suggest that Δ9-THC depresses glutamate synaptic transmission via CB1 receptor activation, affecting glutamate release, inhibiting receptors and transporters function, reducing enzyme activity, and disrupting glutamate synaptic plasticity after prolonged exposure.” https://www.ncbi.nlm.nih.gov/pubmed/26987641
- “The endocannabinoid system provides a framework for many of cannabis’ protective benefits. The cannabinoid type I and II receptors (CB1 and CB2) are powerful regulators of glutamate release, can be anti-inflammatory, and facilitate anti-oxidant effects.” “This important role for CB receptors supports the benefits of THC, which directly activates CB1 and CB2 receptors, and CBD, which indirectly activates them. CB1 receptors are found on brain cells and their activation by endogenous cannabinoids or THC dampens their communication.Particularly, CB1 receptors have a profound ability to reduce glutamate release, highlighting the potential for prominent cannabinoids to suppress the harmful effects of glutamate following brain trauma. Since excessive glutamate signaling is a main contributor to early stage damage after brain injury, this is an important place to start to limit the risk of severe brain damage and even death.” “How were THC and CBD protective? Reduced glutamate signaling protects brain cells from dying after an injury and cardiovascular event. But the potential for behavioral recovery also depends on the levels of free radicals and brain inflammation. Low doses of THC can be anti-inflammatory, but high-doses may increase inflammation, which highlights the importance of proper dosing.” https://www.leafly.com/…/cannabis-effects-brain-damage…
- “Neuroprotection: CBD oil has been seen to enhance the production of myelin to maintain the myelin sheath structure around neurons. This structure works as a neuroprotector and prevents the neurons from aging and degeneration. People can use it to reduce the frequency of cognitive mental disorders such as Alzheimer’s’, Multiple Sclerosis and Dementia which progress with age. CBD oil can also help in repairing of brain cells and reduction in hyperstimulation” http://www.tgdaily.com/health-opinion/cbd-oil-an-all-natural-supplement-that-supports-healing
- CBD is considered to be a neuroprotectant. This means it can help the brain prevent the overproduction of glutamate. Glutamate acts as a neurotransmitter that allows nerve cells to receive signals to act. Overstimulation can cause cell death and/or cell damage. CBD can help to protect your brain if too much glutamate is produced. https://www.counselheal.com/articles/40153/20190505/is-cbd-a-preventative-treatment.htm
- “Cannabis is blocking excess glutamate: Fixing the gut and avoiding these toxins is key. But finding something that blocks the effects of them would be better. At least for the big pharma industry. This is exactly what they are after. Finding something that can be produced in a lab. That’s why there is a United States patent on cannabinoids. This is why the producer of MMR (Safoni Pasteur) is trying to push a breast cancer medication called Rilutek on autistic “volunteers”. What is the mechanism of Rilutek? You guessed it- it’s a glutamate inhibitor with many side effects. The cost is over $2,000 for 30 pills (not including side-effect-incurred costs). Memantine is a glutamate inhibitor, used in Alzheimer’s patients, who have long-term memory problems similar to autistic individuals. Will it be approved for autism soon? It certainly is pointing in that direction. Please read more here. Desperate demand. Limited supply. Higher profit. You get the point. It has been shown that cannabinoids are helpful for a garden variety of neurological disorders (e.g. those of multiple sclerosis, Alzheimer’s, stroke patients, etc.). Autism was not mentioned, but falls into the same bucket with similar fundamental neurological functionalities. Cannabinoids are known to interact with the glutamate receptor, basically making sure that excess glutamate will not cause the neuron to fire, the brain will cool down and Homeostasis is reestablished. If you integrate the work of Drs. Mechoulam and Russo and use the U.S. government patent paper along with this information, it gets really interesting. Here some highlights of some of the best evidence:
“The ability of glutamate agonists to reverse cannabinoid-induced memory impairments is limited by the behavioral toxicity associated with this class of compounds. Additional difficulties arise when the mnemonic effects of cannabinoids are compared with those of antagonists of glutamatergic receptors. There are several reports suggesting that working-memory (i.e. short term) systems are largely spared by doses of N-methyl-D-aspartate (NMDA) antagonists such as phencyclidine and dizocilpine (MK801) [editor’s clarification: these two are pesticides] that disrupt the consolidation and retrieval of long-term reference memories, while cannabinoids tend to produce the opposite spectrum of effects.”
– Cannabinoids as Therapeutics, Raphael Mechoulam, MD & Ethan Russo, MD
“Although it has been unclear whether cannabimimetic activity plays a role in neuroprotection against glutamate induced neurological injury, the teaching in this field has clearly been that a cannabinoid must at least be an antagonist at the NMDA receptor to have neuroprotective effect.”
-United States Government Patent US6630507, Cannabinoids as antioxidants and neuroprotectants
“In the presence of glutamate alone (100 pM Glu), and in the presence of glutamate and 5 pM cannabidiol (CBD) or 5 pM THC, it was demonstrated that CBD and THC were similarly protective.”
-United States Government Patent US6630507, Cannabinoids as antioxidants and neuroprotectants
At cannabinoid meetings in the past, very few representatives of the pharmaceutical companies were present. Now the picture has changed. At least two synthetic cannabinoids are in advanced phase III clinical trials. Cannabis is currently a Schedule I drug, which federally is defined any substance that does not have any medical purpose, yet they are studying and coming out with the forbidden plants’ main constituent (THC) synthesized in a dish. SR-141716, a CB1 antagonist, developed by Sanofi (also producer of MMR), represents a new type of appetite modulator, and HU-211, developed by Pharmos, is a neuroprotectant in head trauma.
Of course, we do need to address the gastrointestinal system as well. Avoidance of GMO foods, MSG and anything that could harbor glyphosate is imperative! It is of no surprise that many parents see improvement in symptoms just by adding probiotics to the diet, to add those “good” bacteria back that were destroyed by glyphosate. Unfortunately, it probably requires more for the gut to heal. Organic raw juices definitely are a great start. I recently heard about a mother who took her son for a fecal transplant and his symptoms were gone after 2 weeks and now is doing better than ever. More studies are needed to see what the best way to heal an inflamed gastrointestinal system of course, but this all links together just so beautifully.”http://www.phytoelements.com/…
Why Is This Important?
Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters, dopamine, serotonin and GABA are great examples. When glutamate is in excess it is extremely toxic to the brain and nervous system. It can become so excitatory, it is considered a excitotoxin, which means that it overstimulates brain cells to the point of killing them or damaging them enough to cause severe mitochondrial dysfunction (associated with low muscle tone) and neurological inflammation. Excess glutamate is believed to be involved in a variety of neurological and neurodegenerative disorders including autism, obsessive compulsive disorders, hyperactivity disorders, complex motor stereotypes, tics, insomnia, anxiety disorders, seizures, sensory processing disorder, addiction, depression, chronic fatigue, PANS, PANDAS, Alzheimers, and so on. Excess glutamate also impairs methylation and depletes glutathione levels, which are vital for detoxification, controlling inflammation and gut health. Working to lower glutamate/inflammation and balance GABA, is key to improving overall health.
Obviously diet (REID) is one of the most important, if not, the most important step in lowering glutamate. However, this natural option may prove beneficial in helping when experiencing a peak of symptoms related to high glutamate and neurological inflammation, i.e. following consumption of a high glutamate food, trauma or a “flare” from PANS (pediatric autoimmune neuropsychiatric disorder) or PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections). Additionally, working to lower inflammation/glutamate by treating underlying sources inflammation (metals, microbial imbalances, parasites, microglial activation, poor detoxification pathways, various toxins, etc.) will also be hugely beneficial. We’ve personally found homeopathy to be great for this.
I do not have personal experience with all options mentioned in the “Lowering Glutamate” page, nor would I recommend all of them (especially the pharmaceutical options). You will want to read the comments as some of the items used to temporarily lower glutamate, can actual work to increase glutamate/glutamate sensitivity over time.
The information shared within this blog has been gathered by a mother, not a physician, and should not act as medical advice. Under no circumstances shall I, or any contributors and affiliates of the blog, be responsible for damages arising from use of the blog.