Lowering Glutamate | Resveratrol

Resveratrol– found in red grapes, red wine, blueberries, peanuts and dark chocolate, calms microglial activation. “Resveratrol reduced glutamate-induced damages” “Resveratrol interacts with the complex III of the respiratory chain, is a radical scavenger and also suppressor of radical formation in the mitochondria. It reduces the intracellular calcium levels in pre- and postsynaptic neurons and also may inhibit the pro-apoptotic factors in glutamate overflow that occurs, e.g. in excitotoxicity. In cell cultures, glutamate overflow leads to formation of free radicals and results in apoptosis.” https://www.ncbi.nlm.nih.gov/pubmed/23459926 “Our findings reinforce the protective role of this compound in some brain disorders, [...]

Lowering Glutamate | Resveratrol2021-09-16T13:03:16-04:00

Lowering Glutamate | Kudzu (Puerarin)

Kudzu (aka Puerarin)– If you've driven along the highway in the south, you've likely noticed this highly invasive Japanese vine covering nearly everything. From billboards to abandoned buildings, it is everywhere!  In fact, my husband has battled it for so long, that he refers to himself as the Kudzu King, complete with his own pair of "Kudzu King" coveralls.  It wasn't until our journey with our son, that I started to develop a better appreciation for this plant. Kuduz is actually neuroprotective against glutamate! Neuroprotective Effect of Puerarin on Glutamate-Induced Cytotoxicity in Differentiated Y-79 Cells via [...]

Lowering Glutamate | Kudzu (Puerarin)2021-09-16T13:35:27-04:00

Lowering Glutamate | Andrographis

Andrographis (andrographolide)–Most commonly known as popular herb to treat Lyme, but it is also has antiviral, antibacterial, and antiparasitic properties. Most importantly, andrographis inhibits microglial activation (see below).  We have sourced ours from Sage Woman Consulting & Apothecary : Tincture & Leaf/Flower “Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia” “Andrographolide exhibited neuroprotective effects, with accompanying suppression of NF-κB and microglial activation, and reduction in the production of cytokines including TNF-α and IL-1β, and pro-inflammatory factors such as PGE2. Our findings suggest that andrographolide may have therapeutic value in the treatment of [...]

Lowering Glutamate | Andrographis2021-09-22T11:45:16-04:00
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