Lowering Glutamate | Quercetin Flavonoid

Quercetin- Inhibits glutamate release and is found in onion (highest in red onion), raw chili peppers, asparagus, kale, berries, plums, peppers, broccoli, sophora japonica leaf/flowers “These results suggest that quercetin inhibits glutamate release from rat cortical synaptosomes and this effect is linked to a decrease in presynaptic voltage-dependent Ca(2+) entry and to the suppression of PKC and PKA activity.” https://www.ncbi.nlm.nih.gov/pubmed/23933436 Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death “This is the first report on the detailed mechanisms of the protective effect of quercetin on HT22 cells. Onion extract and quercetin may be useful for preventing [...]

Lowering Glutamate | Quercetin Flavonoid2020-05-08T14:44:50-04:00

Lowering Glutamate | Narigenin Flavonoid

Naringenin Flavonoid (found in citrus, grapes, etc.)- ” Furthermore, naringenin induced the brain-derived neurotrophic factor and other neuroprotective cytokines, and markedly improved the survival rates of the neurons 24 h following glutamate exposure. The observed results suggest that the naturally occurring bioflavonoid (naringenin) exerts neuroprotective effects via highly specific molecular targets in neurons.” Protective effect of naringenin on glutamate-induced neurotoxicity in cultured…. Available from:https://www.researchgate.net/publication/276868364_Protective_effect_of_naringenin_on_glutamate-induced_neurotoxicity_in_cultured_hippocampal_cells “There was significant recovery of glutathione content and all the antioxidant enzymes studied. Also in case of behavioural parameters studied, naringenin showed decrease in seizure severity. All these changes were supported by histological [...]

Lowering Glutamate | Narigenin Flavonoid2019-06-23T09:30:21-04:00

Lowering Glutamate | Luteolin Flavonoid

Luteolin- A type of flavonoid found in celery, chamomile, carrots, celery, parsley, thyme, oregano, sage, basil, peppermint, artichoke and spinach is known to reduce brain and systematic inflammation by CALMING MICROGLIAL CELLS and therefore lower glutamate and cytokine levels (microglia are activated as a first step in immune response and they signal additional glutamate). Mixing these food sources with coconut oil or olive oil will help increase absorption. It is also a strong inhibitor of mast cells and helps autoimmune disorders with the reduction of immune cells. Luteolin has also been shown to stimulate brain repair, reduce exitotoxicity (from [...]

Lowering Glutamate | Luteolin Flavonoid2019-05-05T08:19:16-04:00

Lowering Glutamate | Hesperidin Flavonoid

Hesperidin Flavonoid (found in citrus peel)- neuroprotective against glutamate excitotoxicity. “The citrus flavonoid hesperidin exerts neuroprotective effects and could cross the blood-brain barrier. Given the involvement of glutamate neurotoxicity in the pathogenesis of neurodegenerative disorders, this study was conducted to evaluate the potential role of hesperidin in glutamate release and glutamate neurotoxicity in the hippocampus of rats.)””These results demonstrate that hesperidin inhibits evoked glutamate release in vitro and attenuates in vivo KA-induced neuronal death in the hippocampus. Our findings indicate that hesperidin may be a promising candidate for preventing or treating glutamate excitotoxicity related brain disorders [...]

Lowering Glutamate | Hesperidin Flavonoid2019-05-05T07:27:25-04:00

Lowering Glutamate | Apigenin Flavonoid

Apigenin flavonoid- Found in chamomile, parsley, celery, thyme, lemon balm, cloves, etc.) After years of homeopathy, we discovered that the best remedy during a “flare” or times that we may be a little off, was a low dose of the homeopathic remedy, chamomilla.  So I decided to do a little research and of course discovered that it inhibits glutamate because of its high concentration of the flavonoid, apigenin. “The flavonoid inhibited also peak amplitude and frequency of spontaneous postsynaptic excitatory currents (sEPSCs). Finally, apigenin is neuroprotective against glutamate-induced neurotoxicity in cerebellar and cortical neurons in culture. Our [...]

Lowering Glutamate | Apigenin Flavonoid2019-04-10T09:04:26-04:00
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