Lowering Glutamate | B12

Vitamin B12- found in beef, liver, chicken, clams, and tuna. “Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Chronic administration of methylcobalamin protects cultured retinal neurons against N-methyl-D-aspartate-receptor-mediated glutamate neurotoxicity, probably by altering the membrane properties through SAM-mediated methylation.” https://www.ncbi.nlm.nih.gov/pubmed/9112980 “Vitamin B12 enhances GABA content but reduces glutamate content in the rat suprachiasmatic nucleus.” https://www.ncbi.nlm.nih.gov/pubmed/9249572 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or [...]

Lowering Glutamate | B122021-09-16T12:27:52-04:00

Lowering Glutamate | Vitamin C

Vitamin C- Vitamin C is intertwined with glutamate signaling and glutamate release. It has the ability to neutralize free radicals, reduce oxidative stress, improve mitochondrial function, and offer protection during glutamate release. The use of whole food sources such as rose hips, Camu Camu, guava, kiwi, strawberry, cherry, blackberry, blueberry, raspberry, beet, carrot, spinach, broccoli, kale, cabbage, parsley, brussel sprouts, ginger, cauliflower, cranberries, asparagus, etc. are much preferred over supplementation in my opinion (glutamate risk and may contribute to oxalate issues). “Vitamin C also has antioxidant properties that may prove to be helpful in treating HD. [...]

Lowering Glutamate | Vitamin C2021-09-16T12:29:42-04:00

Lowering Glutamate | Zinc

Zinc-  It is important to note that zinc and copper need to be in balance and supplementing with one can disrupt this balance. New study presents a working model that could point to a better understanding of autism’s underpinnings. “The new study, led by Stanford neuroscientists John Huguenard, PhD, and Sally Kim, PhD, and then-graduate student Huong Ha, PhD, showed that zinc is required for the proper behavior of two related proteins, Shank 2 and Shank 3, that hang out at most synapses in the brain. Among their duties, Shank 2 and Shank 3 can reshuffle [...]

Lowering Glutamate | Zinc2021-09-16T12:37:46-04:00

Lowering Glutamate | Drug Options

Pharmaceutical & Drug Options ****I WOULD NOT ENCOURAGE THE USE OF MOST OF THESE DRUGS**** “There are many drugs that target your GABA receptors like Ativan, Xanax, Klonipin, Valium, and Neurontin (Gabapentin) and others. These drugs look similar in chemical structure as gamma-aminobutyric acid so they can fit in your GABA receptors, which artificially stimulates them, but they do not actually increase production. Therefore they do not address the underlying problem of not producing enough, because there must be some level of GABA present in order for these drugs to have an effect. Furthermore, anytime a substance [...]

Lowering Glutamate | Drug Options2021-09-16T12:39:28-04:00

Lowering Glutamate | B6

Vitamin B6- found in fish, liver, organ meats and potatoes. “The biochemistry of vitamin B6 is basic to the cause of the Chinese restaurant syndrome” https://www.ncbi.nlm.nih.gov/pubmed/6724532 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters, dopamine, serotonin and GABA are great examples. When glutamate is in excess it is extremely toxic to the [...]

Lowering Glutamate | B62021-09-16T12:41:18-04:00

Lowering Glutamate | B3

Vitamin B3 (Niacin, Nicotinic Acid)- Found high in liver, anchovies, tuna, chicken breast I would not encourage the use of this supplement unless you are well aware of your methylation status. “Nicotinic acid requires SAMe to be metabolized. SAMe is a major methyl donor. Thus, when one consumes niacin, SAMe gets used up and methyl donors drop. Thereby excessive methylation goes away. Nicotinic acid also supports the elimination of glutamate. Many with elevated levels of glutamate do not do well with methylfolate or any type of folate until the levels of glutamate are balanced.” [...]

Lowering Glutamate | B32021-09-16T12:54:32-04:00

Lowering Glutamate | B1 (Thiamine)

Vitamin B1 (Thiamine)- found in sunflower seeds, macadamia nuts, beans & lentils helps to convert glutamine to GABA “Extracellular glutamate is increased in thalamus during thiamine deficiency-induced lesions and is blocked by MK-801.” https://www.ncbi.nlm.nih.gov/pubmed/8245970 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters, dopamine, serotonin and GABA are great examples. When glutamate [...]

Lowering Glutamate | B1 (Thiamine)2021-09-16T12:56:43-04:00

Lowering Glutamate | Valerian Root

Valerian Root – Increases GABA. “ In addition, pretreatment with valerian extract or valerenic acid decreased the brainstem inhibitory effects produced by muscimol (both P < 0.05), suggesting that these compounds play an important role in the regulation of GABAergic activity. Data from this study suggest that the pharmacological effects of valerian extract and valerenic acid are mediated through modulation of GABA(A) receptor function” https://www.ncbi.nlm.nih.gov/pubmed/14742369 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites [...]

Lowering Glutamate | Valerian Root2021-09-16T12:59:58-04:00

Lowering Glutamate | Theanine

Theanine, L-Theanine  L-Theanine use has been growing as it is more commonly used to help balance glutamate and GABA, by increasing GABA and blocking glutamate receptors.  However L-theanine is also a glutamate analog, and what may work for some, may not work for all.  If you have trouble converting glutamate to GABA, this may actually contribute to the imbalance between these two neurotransmitters, by increasing glutamate.  If you are unaware of how well you're able to convert glutamate to GABA or have a sensitivity to caffeine or mushrooms (what the supplement is typically derived from) you [...]

Lowering Glutamate | Theanine2021-09-16T11:51:58-04:00

Lowering Glutamate | Taurine

Taurine–Beef, lamb, dark chicken meat and eggs are food sources of taurine. Why is taurine from whole food important? Commercial taurine supplements can increase sulfur which may already be high due to certain gene mutations.  Additionally, the toxins associated with yeast/candidia (which is very common) can end up depleting taurine.  Since taurine is so important in the conversion of glutmate to GABA and as an inhibitory neurotransmitter, it is important that adequate levels are achieved through diet. “The amino acid taurine increases the GAD enzyme and consequently GABA levels. Additionally taurine doubles as an inhibitory neurotransmitter [...]

Lowering Glutamate | Taurine2021-09-16T12:59:06-04:00
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