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Thoughts on the Glutamate Autism Connection

After following diet changes and doing some research, I started to get a better understanding of the role of excess glutamate in many health issues.  There is a huge connection between excess glutamate and autism.  In my opinion, dietary sources of free glutamate in addition to intrinsic glutamate or glutamate signaling produced by the body, play a much bigger role in health issues than we realize. Due to the number of glutamate receptors throughout the brain and its regulation of over 50% of our nervous system, I personally believe excess glutamate is a central mechanism behind the [...]

Thoughts on the Glutamate Autism Connection2023-03-24T10:04:25-04:00

Looking at Glutamate in Underlying Infections & Immune Dysfunction (PANS, PANDAS, AE, Lyme, etc)

PANS & PANDAS Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) diagnosis has jumped to 1 in 200 hundred and is becoming more and more common. These disorders are distinguishing by an often striking onset of neuropsychiatric symptoms in response to immune activation and possibly misdirected immune response. While PANS can be triggered by numerous infections, PANDAS is just associated with the strep infection. Symptoms of PANS & PANDAS Tics Obsessions/Compulsions/OCD Anxiety Headaches/Migraines ADHD Food Restrictions Personality Changes Emotional Lability Sleep Disturbances Mood Disorders Regression of Skills/Grades Urinary Frequency What [...]

Looking at Glutamate in Underlying Infections & Immune Dysfunction (PANS, PANDAS, AE, Lyme, etc)2019-10-08T10:13:07-04:00

Lowering Glutamate | Resveratrol

Resveratrol– found in red grapes, red wine, blueberries, peanuts and dark chocolate, calms microglial activation. “Resveratrol reduced glutamate-induced damages” “Resveratrol interacts with the complex III of the respiratory chain, is a radical scavenger and also suppressor of radical formation in the mitochondria. It reduces the intracellular calcium levels in pre- and postsynaptic neurons and also may inhibit the pro-apoptotic factors in glutamate overflow that occurs, e.g. in excitotoxicity. In cell cultures, glutamate overflow leads to formation of free radicals and results in apoptosis.” https://www.ncbi.nlm.nih.gov/pubmed/23459926 “Our findings reinforce the protective role of this compound in some brain disorders, [...]

Lowering Glutamate | Resveratrol2021-09-16T13:03:16-04:00

Lowering Glutamate | Andrographis

Andrographis (andrographolide)–Most commonly known as popular herb to treat Lyme, but it is also has antiviral, antibacterial, and antiparasitic properties. Most importantly, andrographis inhibits microglial activation (see below).  We have sourced ours from Sage Woman Consulting & Apothecary : Tincture & Leaf/Flower “Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia” “Andrographolide exhibited neuroprotective effects, with accompanying suppression of NF-κB and microglial activation, and reduction in the production of cytokines including TNF-α and IL-1β, and pro-inflammatory factors such as PGE2. Our findings suggest that andrographolide may have therapeutic value in the treatment of [...]

Lowering Glutamate | Andrographis2021-09-22T11:45:16-04:00

A Story of Hope with REID: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

We occasionally get letters or comments from parents that have seen improvements in health with REID. To help provide hope to so many still in the trenches, I’ve decided to make more of an effort to share some these comments (with their permission, of course). Many of us don’t have it all figured out, but we cling to the hope and words of progress. Everyone’s journey is different, diet changes may not reap huge changes for all, but it is absolutely helping some. Like this family, glutamate and the REID diet have been a huge piece to [...]

A Story of Hope with REID: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)2019-09-29T17:03:53-04:00
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