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Lowering Glutamate | Selenium

Selenium- One brazil nut per day should give you the daily recommended amount of selenium needed. “These results suggest that glutamate targets the mitochondria and selenium supplementation within physiological concentration is capable of preventing the detrimental effects of glutamate on the mitochondria” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378533/42 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters, [...]

Lowering Glutamate | Selenium2021-09-16T13:02:17-04:00

Lowering Glutamate | Quercetin Flavonoid

Quercetin- Inhibits glutamate release and is found in onion (highest in red onion), raw chili peppers, asparagus, kale, berries, plums, peppers, broccoli, sophora japonica leaf/flowers. However, we have also used this supplement. “These results suggest that quercetin inhibits glutamate release from rat cortical synaptosomes and this effect is linked to a decrease in presynaptic voltage-dependent Ca(2+) entry and to the suppression of PKC and PKA activity.” https://www.ncbi.nlm.nih.gov/pubmed/23933436 Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death “This is the first report on the detailed mechanisms of the protective effect of quercetin on HT22 cells. Onion extract [...]

Lowering Glutamate | Quercetin Flavonoid2023-09-22T12:09:41-04:00

Lowering Glutamate | Pyrroloquinoline Quinone (PQQ)

Pyrroloquinoline quinone (PQQ)- Widely found in bacteria and foods such as spinach, celery, parsley, kiwi papaya and beans. It is known to stimulate the production and efficiency of mitochondria, protects against free radicals and reduces nitric oxide production. Defiencies in PQQ are associated with immune deficiency, dry skin, infertility and low overall fitness. “our results indicated that PQQ could protect primary cultured hippocampal neurons against glutamate-induced cell damage by scavenging ROS, reducing Ca2+ influx, and caspase-3 activity, and suggested that PQQ-activated PI3K/Akt signaling might be responsible for its neuroprotective action through modulation of glutamate-induced imbalance between Bcl-2 [...]

Lowering Glutamate | Pyrroloquinoline Quinone (PQQ)2021-09-16T13:08:01-04:00

Lowering Glutamate | Narigenin Flavonoid

Naringenin Flavonoid (found in citrus, grapes, etc.)- ” Furthermore, naringenin induced the brain-derived neurotrophic factor and other neuroprotective cytokines, and markedly improved the survival rates of the neurons 24 h following glutamate exposure. The observed results suggest that the naturally occurring bioflavonoid (naringenin) exerts neuroprotective effects via highly specific molecular targets in neurons.” Protective effect of naringenin on glutamate-induced neurotoxicity in cultured…. Available from:https://www.researchgate.net/publication/276868364_Protective_effect_of_naringenin_on_glutamate-induced_neurotoxicity_in_cultured_hippocampal_cells “There was significant recovery of glutathione content and all the antioxidant enzymes studied. Also in case of behavioural parameters studied, naringenin showed decrease in seizure severity. All these changes were supported by histological [...]

Lowering Glutamate | Narigenin Flavonoid2021-09-16T13:11:16-04:00

Lowering Glutamate | Moringa

Moringa and Glutamate Moringa has shown to help mitigate the damages of dietary monosodium glutamate by modifying liver function, oxidative stress, DNA damage, kidney injury, liver injury, and PCNA expression. Roles of Moringa oleifera Leaf Extract in Improving the Impact of High Dietary Intake of Monosodium Glutamate-Induced Liver Toxicity, Oxidative Stress, Genotoxicity, DNA Damage, and PCNA Alterations in Male Rats https://www.hindawi.com/journals/omcl/2018/4501097/ "Monosodium glutamate (MSG) produces adverse and damaging effects in different organs like liver and kidneys. Moringa causes ameliorating effect on kidney and liver injury induced by monosodium glutamate in rats."  Ameliorating Effect of Moringa against Liver and [...]

Lowering Glutamate | Moringa2021-09-16T13:12:16-04:00

Lowering Glutamate | Passion Flower

Passion Flower- is known to increase levels of GABA in the brain, calm, decrease anxiety, improve sleep, improve liver function, and help to recover from adrenal fatigue. "The properties in passionflower are thought to promote calming effects by increasing the levels of the chemical gamma-aminobutyric acid (GABA), which reduces the activity of some neurons that cause anxiety." https://www.drweil.com/vitamins-supplements-herbs/herbs/passionflower/ "Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941540/ "Passionflower (Passiflora incarnata) was used traditionally in the Americas and later in Europe as a calming herb for [...]

Lowering Glutamate | Passion Flower2021-09-16T13:15:27-04:00

Lowering Glutamate | Honokiol (Magnolia Bark)

Honokiol (connected to magnolol) also known as Magnolia Bark Extract , is rapidly gaining in popularity due to its ability to help relive the symptoms many aliments associated with excess glutamate.  Honokiol helps to convert excess glutamate into GABA. While it is primarily known to help combat cancer, inflammation, depression, sleep disturbances, EBV, Lyme and manage pain, it also carries quite a few risks, especially when recreationally misused.  Please do your own research and consult with your medical provider before starting this one as it impacts benzodiazepine sites. This is just a brief overview of what [...]

Lowering Glutamate | Honokiol (Magnolia Bark)2021-09-16T13:16:33-04:00

Lowering Glutamate | Melatonin

Melatonin-  Melatonin is often just associated with sleep and there is a huge connection between sleep disturbances and an imbalance in glutamate (excites) and GABA (calms). Our children lean towards excess glutamate which will make them more prone to sleep disturbances. The smallest amount of glutamate would wake my son for 2-3 nights. Melatonin and glutamate have a complicated relationship.  It appears as though melatonin protects against excess glutamate AND glutamate inhibits melatonin (fluoride and aspartate/aspartame do as well). Some Foods/Herbs Highest in Melatonin Tart cherries Asparagus Walnuts Almonds Pomegranate Raspberries Broccoli Cucumber Mustard seeds Fenugreek [...]

Lowering Glutamate | Melatonin2021-09-16T13:17:23-04:00

Lowering Glutamate | Magnesium

Magnesium- In our experience, magnesium has made the most significant impact in reducing our symptoms within a flare. Magnesium protects against glutamate damage, sits on the NMDA glutamate receptor, calms cells, helps to raise GABA, improves motility, is a potent antioxidant, increases glutathione, and can help to resolve many various health issues. It is also my understanding that one will quickly burn through magnesium due to neuron firing when in an excitotoxic state (or a flare). Low magnesium is also associated with oxidative stress and a significant fall in cellular glutathione, low vitamin D, and a dramatic [...]

Lowering Glutamate | Magnesium2023-04-04T12:40:57-04:00

GRAINS, NUTS, SEEDS & BAKING PRODUCTS

I feel like I need to include every sort of disclaimer here because some of these foods are not perfect, and I am sure many will find reasons to criticize them. However, I will absolutely admit how hard it can be to switch your family to a whole food-based diet when coming from the standard American diet. While some of these foods are not ideal and can be very inflammatory due to poor quality oils, sugar, non-organic, high in x,y,z, etc., they may help reduce free glutamate exposure or are slightly cleaner options when switching to [...]

GRAINS, NUTS, SEEDS & BAKING PRODUCTS2023-05-02T11:28:23-04:00
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