Honokiol (connected to magnolol) also known as Magnolia Bark Extract , is rapidly gaining in popularity due to its ability to help relive the symptoms many aliments associated with excess glutamate. Honokiol helps to convert excess glutamate into GABA. While it is primarily known to help combat cancer, inflammation, depression, sleep disturbances, EBV, Lyme and manage pain, it also carries quite a few risks, especially when recreationally misused. Please do your own research and consult with your medical provider before starting this one as it impacts benzodiazepine sites. This is just a brief overview of what I have found on the connection. You may find some additional information here.
“Honokiol is a poly-phenolic compound that exerts neuroprotective properties through a variety of mechanisms. It has therapeutic potential in anxiety, pain, cerebrovascular injury, epilepsy, and cognitive disorders including Alzheimer’s disease. It has been traditionally used in medical practices throughout much of Southeast Asia, but has now become more widely studied due to its pleiotropic effects. Most current research regarding this compound has focused on its chemotherapeutic properties. However, it has the potential to be an effective neuroprotective agent as well” “Glutamic acid decarboxylase (GAD) is an enzyme involved in GABA synthesis, and the activity of hippocampal GAD was significantly increased in honokiol-treated mice, suggesting that honokiol may alter the brain’s synthesis of GABA (47).” “Honokiol is not entirely without risks, although its limited empirical application to humans at therapeutic doses has limited the evaluation of its side effect profile thus far. There are potential risks that can be expected, including increased bleeding and potential neurotoxicity at high doses. Honokiol has been found to be a potent inhibitor of arterial thrombosis, so it may be advisable to avoid honokiol in coagulopathic patients or in those where bleeding or hemorrhage may be of concern (13). These may include patients with hemorrhagic stroke, patients with hemorrhagic changes following ischemic stroke, patients on coumadin or therapeutic lovenox, and patients with clotting disorders such as hemophilia or von Willebrand’s deficiency. And, while honokiol has been found to have neuroprotective effects at low doses, it has also been found to increase neuronal death in vitro at higher doses (100 μM applied directly to fetal cortical neurons) (38).” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769637/
“Recently, we have observed that honokiol and magnolol, isolated from the bark of Magnolia officinals[8, 9], possess the ability to block the glutamate receptor-mediated intracellular cation signals  and inhibit glutamate-induced cell damage . According to the above evidence, it is proposed that honokiol and magnolol may have the potent analgesic activity via blockade of glutamate receptors.” https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-16-94