By now you’ve likely discovered that we have struggled with many food sensitives and food intolerances. To clarify,
- Food allergies (IgE) typically result in an immediate physical reaction (anaphylactic response, hives, swelling, tingling of lips, vomiting, dizziness, shortness of breath) and are often life threatening.
- Food sensitivities (IgG) can, not only result in physical symptoms similar to a true allergy (IgE), but also include a wide array of behavioral and/or developmental symptoms due to specific foods. The primary difference between a food sensitivity and food allergy is the amount of time between consumption and when the symptoms occur. Food sensitivities often cause a behavioral or physical reactions in the days following consumption. Because of this delayed reaction, food sensitivity (IgG) testing and/or a food or behavior journal is key. Food sensitivities are often associated with “leaky gut” and the more inflamed the body is, the more sensitive/reactive they will be. The body can easily become very reactive, particularly if one is consuming a lot of the same restrictive foods over and over again.
- Food intolerances often are representative of classes of food, and may present similarly to an IgE food allergy and/or an IgG food sensitivity because of the ability to create an immediate and delayed onset of symptoms. However, the intensity of an immediate onset of symptoms related to a food intolerance are often less severe and more behavioral than a food allergy. Symptoms of a food intolerance can vary from head banging, rashes/hives, developmental delays, GI discomfort, fatigue, dark circles under the eyes, hyperactivity, sleep issues, red face/ears, etc Food intolerances may often originate from lack of specific enzymes, inability to metabolize certain foods, gene mutations, imbalances and inflammation. Some examples of food intolerances are reactions to histamines, phenols/salicylates, sulfur, oxalates, gluten and dairy.
Some of the most common foods to cause the above reactions are:
- Tree nuts (almonds, pistachios, walnuts, pecans, cashews, hazelnut, macadamia nuts, Brazil nuts, chestnuts)
- Chicken Eggs
Biggest takeaway, is that food sensitivities and food intolerances present similarly by often having an immediate and delayed behavioral, physical and developmental reactions. The why does my child do this post may help determine which foods you may be reacting to. During the time we’ve worked to overcome his reactions, I have been able to connect some of the dots but please remember I am just a mom and I just trying to share some of our discoveries. Also, please keep in mind that this doesn’t address any behavioral reaction caused by an imbalance in diet triggering an overgrowth of other pathogens like yeast, clostridia, etc. ( and/i.e. drinking a cup full of juice and causing a surge in sugar). These are also just the most common issues discussed and doesn’t fully address the role of gene SNP’s. Again, we found a food/behavior journal (see this post for more info.) and/or a REID compliant rotation diet may be beneficial in discovering/resolving some of these issues.
Phenols (salicylates are a type of phenol) are a chemical compound naturally found in foods. Typically the brighter/more colorful the food, the higher in phenols. One becomes more sensitive to these if their bucket is already full from phenols produced by various metabolites or if they have trouble with phenol sulfotransferase deficiency (PST) which should be indicated on a 23 & me SNP’s test. I think of the phenol issue like a bucket. Small amounts of phenols can start to fill the bucket with no reaction, but once the phenol level gets so high, that the bucket tips/overflows, you’ll see a reaction. A typical reactions to phenols and/or salicylate may be overly giggly, red ears or flushed cheeks, aggression, irritability, night waking, tics, defiance, emotional, dark circles under eyes, and hyperactivity.
We did briefly struggle with a phenol/salicylate intolerance when his diet was low in fiber and high in meat. Aromatic amino acids concentrated in meat protein are the biggest culprit of phenol metabolites that interfere with dopamine metabolism. Clostrida (which can also be a result of a high protein diet) and SIBO (often associated with carbohydrate fermentation) will also create phenols as a byproduct. As these proteins ferment in the gut, phenols will be produced. The proteins are broken down into amino acids and metabolites/bacteria that metabolize these amino acids create phenols/inflammation as a byproduct.
These high levels of phenols will easily fill the “bucket”, resulting in a reaction to additional phenols from diet. In my opinion, this is why many cannot tolerate any additional phenols in diet. Glutamate signaling is also created in this process due to the inflammatory response and fermentation of the protein in the gut. I would try balancing the diet further (increasing high fiber leafy greens and reducing meat) to eliminate the possibility of excess phenols from this process. Dr. Reid recommends roughly 75% of diet to come from high fiber green veggies. We try to make that’s goal, although it doesn’t always happen. We also limit meat to once a day. We still eat phenols/salicylates but do not go overboard so that our “bucket” doesn’t tip resulting in a reaction.
Dr. Reid also recommends using herbs to combat some of the underlying inflammation (clostridium, SIBO, etc.)
“Protein fermentation mainly occurs in the distal colon, when carbohydrates get depleted and results in the production of potentially toxic metabolites such as ammonia, amines, phenols and sulfides.” https://www.ncbi.nlm.nih.gov/pubmed/22121108
“One mechanism that could explain the association with meat is increased colonic protein metabolism due to increased protein intake from high meat diets. Products of colonic protein degradation and metabolism include ammonia, phenols, indoles and amines which have been shown to exert toxic effects in vitro and in animal models. These compounds are present in faecal samples suggesting that they may exert gut mucosal effects. Human studies have shown that colonic protein metabolism via the gut microflora is responsive to dietary protein as fecal ammonia and urinary phenolic compound concentrations increase in response to increased intake of protein rich foods.” http://www.caister.com/ciim/v/v1/05.pdf
TACA Resource on Phenols & Salicylates: https://www.tacanow.org/family-resources/phenols-salicylates-additives/
Many with autism and various other health issues are very sensitive to oxalates and there may be many reasons for this (glyphosate, oxidative stress, lack of proper bile production, vitamin K, etc). I found the glutamate and oxalate connection rather interesting. Glutamate induces oxidative stress which is an endogenous producer of oxalate. While magnesium is good and can sit on the glutamate receptor, it needs to be higher than calcium levels. Leafy greens are necessary for vitamin K, magnesium, fiber fermentation, etc. If you are struggling with oxalate issues (sandy stools, oxalate crystals in diapers, frequent urination, etc.) you may want to choose leafy greens lower in oxalate, lower consumption of nuts and other high oxalate foods. Bifido bacteria can also degrade oxalate, which often comes from the metabolism of olgiosaccharides- asparagus, Jerusalem artichokes, bananas, oats are some of the foods that contain it.
“Vitamin K is very important for GABA and glutamate balance as well, as it is needed for healthy calcium metabolism where it reacts with glutamate and calcium to deliver calcium to the bones and teeth, and it prevents accumulation of excess calcium which would contribute to cell death. Vitamin K is a fat-soluble vitamin; however, unlike other fat soluble vitamins, it is not stored in the body and must be consumed on a daily basis. Typically, vitamin K is produced when the friendly flora in our gut process leafy greens, but if dysbiosis is present or you’re not eating leafy greens, then vitamin K is not produced in sufficient numbers and deficiency may develop.
The pancreas uses Vitamin K abundantly for sugar regulation. In addition to the brain, the pancreas is also very vulnerable to accumulation of excessive glutamate or other excitotoxins, which will further impair regulation of sugar. As we discussed previously, too much or too little insulin or glucose can both contribute to excess glutamate Therefore, keeping glutamate and GABA in balance is critical for the health of the pancreas and all its functions and the health of the pancreas is vital for maintaining the balance.”http://www.holistichelp.net/…/how-to-increase-gaba-and…/
“In this paper I am proposing that a deficiency in Vitamin K causes unregulated calcium movement and deposition in the body of the autistic child, and that unregulated calcium is a cause of many of the symptoms associated with autism. I am also proposing that a Vitamin K deficiency is the cause of the calcium oxalate crystals found in many autistic children.
Calcium, in tandem with the neurotransmitter glutamate, is essential to the functioning of the excitatory cells of the nervous system: once glutamate opens the neuronal cell’s calcium channel, calcium pours into the channel and triggers the neuron to fire. The concentration of glutamate within the nervous system is therefore carefully regulated by the nervous system (specifically the astrocytes, which can be negatively affected by mercury and by neurotoxins produced by Lyme spirochetes) because excess glutamate will keep the calcium channels open, allowing calcium to continue to enter, and excite, the neurons. Dr. Russell Blaylock, among others, has written extensively about the neurotoxicity associated with an excess of glutamate. However, I believe that unregulated calcium may play an unappreciated role in triggering the incessant neuronal firing and resultant cell death that are a hallmark of excess glutamate in the nervous system. If a child is unable to regulate calcium due to a Vitamin K deficiency, that child may display signs of glutamate toxicity and uncontrolled neuronal firing that manifest as the cluster of behavioral disorders called autism.” “A Vitamin K deficiency may be a contributing factor in the autistic child’s endogenous production of oxalic acid, which can bind to and immobilize calcium. If the renegade calcium is bound to oxalates it cannot make its way into the nervous system and cause damage. The human body seems to have a reason for producing oxalic acid: to control and manage calcium. It also has the means to dispose of it once the diet contains adequate Vitamin K again: the Vitamin K triggers carboxylation of bone proteins, which can then chelate the calcium from the crystals and put the calcium where it belongs. Meanwhile the oxalic acid will be disposed of, via secretion either through the kidney tubules or across the intestinal membrane. However, if the kidney tubules are not filtering well due to the presence of CaOx crystals, or if the intestines do not contain oxalate-degrading bacteria, then the oxalic acid will remain in the body and re-crystallize. Disposal of any other waste product or toxin will be compromised also.” “Vitamin K appears to be capable of chelating the calcium from calcium oxalate crystals, thus dissolving them and opening up the kidney tubules as another avenue for disposal of soluble oxalate. As CaOx crystals deposited around the body begin to dissolve, the autistic child’s behavior should improve.” http://www.gutresearch.com/VitaminK.pdf
“Dr. Clive Solomons found that, if the diet is very low in oxalates, the dieter would begin to produce oxalates endogenously. The very-low-oxalate dieter is by definition eating few or no leafy greens, the main dietary source of Vitamin K1, lending some credence to the hypothesis that a Vitamin K deficiency is one reason the liver would manufacture soluble oxalates.” http://pddhelp.com/forum/viewtopic.php?t=8032
See my blog post on our experience with it here.
We love to travel but things can quickly become complicated when you’re on a special diet. The last thing you want is to be stressed while on vacation! Here are some of the ways in which we’ve navigated traveling. Read More
Early on in our journey I found this amazing symptom checklist from, The River to Recovery blog . Unfortunately, it didn’t include glutamate or symptoms related to excess glutamate so I was always kind of guessing until I was able to research further. With the creation on the Facebook group, I found many others were looking for the same sort of checklist for glutamate symptoms as well and thus this list was created. The majority of these are based on our personal experience or with information we’ve discovered along the way. Hopefully, this will serve as a sort of guide to help discover what may be part of the root cause for many behavioral issues we face with our children and ourselves.
Aggressive Behavior: excess glutamate, hypoglycemia, allergies, food sensitivities, phenols, pain, constipation, microbial imbalances, adrenals, PANS, PANDAS
Anxiety: excess glutamate, microbial imbalances, yeast, PANS, PANDAS, LYME, overall inflammation, viral load
Anti-social: excess glutamate/low GABA
Bad Breath: Yeast, ketosis/too low carb, dehydration, low zinc, strep, microbial imbalances
Biting: see sensory seeking
Bloating (aka Buddha Belly): SIBO, histamine, yeast, die-off, clostridia, constipation, oxalate dumping
Chapped Lips: yeast, dehydration, low b-vitamins
Chewing on things: low zinc, low magnesium, yeast
Climbing: see sensory seeking
Dark Circles Under Eyes: food allergies, food sensitivities, environmental allergies, poor detoxification, inflammation, histamine, mast cell activation
Defiance: excess glutamate, phenols, food sensitivities
Dry Skin: food sensitivities, food allergies, need for essential fatty acids, histamine, mast cell activation, low B-vitamins
Ear Wax (Abundant): yeast, food sensitivities, acute illness, need for essential fatty acids, histamine, allergies
Echolalia: excess glutamate, microbial imbalances
Eczema: allergies, food sensitivities, environmental allergies, histamine, mast cell activation
Emotional: hypoglycemia, adrenals, phenols, PANS, PANDAS, excess glutamate
Eye Contact (Poor): excess glutamate/low GABA, low vitamin A, yeast, microbial imbalances, low zinc
Fatigue: excess glutamate, adrenal fatigue, mast cell activation, mitochondrial dysfunction, LYME
Fine Motor Delay: mitochondrial dysfunction, excess glutamate, gross motor delay, retained primitive reflexes
Flushed Skin (face/ears): phenols, detox, histamine, mast cell activation, food allergy, food sensitivity, environmental allergy
Flexed or Crunched Fingers: excess glutamate
Frequent Urination: detox, oxalate dumping, excess glutamate, low magnesium, PANS, PANDAS, constipation
Gas: GI inflammation, food allergies, food sensitivities, trouble processing sulfur (smelly), yeast, microbial imbalances (smelly), constipation (smelly)
Grinding Teeth: parasites, excess glutamate (specifically in the basal ganglia), low magnesium, yeast, microbial imbalances
Hand Flapping: see stimming
Hitting/Pushing/Pressing on you: GI inflammation, see sensory seeking
Holding Privates: yeast, oxalate dumping
Hyperactivity: excess glutamate, yeast, food sensitivity, phenols, see sensory seeking
Humping: yeast, constipation, histamine, oxalate dumping, see sensory seeking
Irritability: excess glutamate, adrenals, detox, food sensitivity, hypoglycemia, histamine, low magnesium, low B vitamins, PANS, PANDAS
Itchy Eyes: histamines, oxalate, low vitamin K
Itchy Bottom: parasites, yeast
Joint Pain: excess glutamate, high inflammation, food sensitivities, LYME, mold exposure, oxalate dumping, need for essential fatty acids, PANS, PANDAS, mold exposure
Jumping (around/couch cushions): see sensory seeking & stimming
Laughing Inappropriately: yeast, phenols, ammonia, microbial imbalances
Lining Things Up: Excess glutamate (specifically around basal ganglia), yeast, low magnesium, microbial imbalances, see visual stimming
Looking out of Corner of Eye/Dropping Things/Looking at things Closely: see visual stimming
Low Muscle Tone/Gross Motor Delay: mitochondrial dysfunction, excess glutamate, high underlying inflammation, retained primitive reflexes, cerebral folate deficiency (CFD),
Migraines: excess glutamate, low magnesium, food sensitivities
Night Terrors: excess glutamate, food allergies, food sensitivities, microbial imbalances, PANS, PANDAS, parasites
Night Waking: excess glutamate, detox, phenols, histamine, low magnesium, low melatonin, hypoglycemia, inflammation
Obsessive Compulsive Disorder: excess glutamate, low magnesium, neuro-inflammation, microbial imbalances,
Pacing: excess glutamate, yeast, GI inflammation (see stimming)
Picky Eating: Excess dietary glutamate, yeast, low zinc, microbial imbalances, EoE, constipation, see sensory & reflux
PICA: low zinc, low iron, parasites, yeast
Pressing Abdomen on Things: GI Inflammation, constipation, food allergies, food sensitivities
Red Ring Around Mouth: yeast, food allergies, food sensitivities, histamine
Red Ring Around Bottom: yeast, food allergies, food sensitivities, microbial imbalances,
Restless Legs- excess glutamate
Rocking: see stimming
Self-Injurious Behavior/Head Banging/Biting: allergies, phenols, GI inflammation, microbial imbalances, see sensory seeking
- Noise: excess glutamate, low magnesium, yeast, inflammation
- Smells: excess glutamate, low zinc
- Light: excess glutamate, adrenals, mold exposure
- Textures: excess glutamate, low zinc
Separation Anxiety: excess glutamate, PANS, PANDAS, viral load, microbial imbalances
Sensory Seeking: excess glutamate, low magnesium, neuro-inflammation, GI inflammation yeast, microbial imbalances, retained primitive reflexes
Speech Delays: excess glutamate/low GABA, motor planning/apraxia, need for essential fatty acids, overall inflammation, underlying infections, cerebral folate deficiency (CFD)
Spinning: see sensory seeking & visual stimming
Spit Bubbles: yeast
Strabismus (one eye turns inwards): excess glutamate
- Visual Stimming: excess glutamate (specifically around basal ganglia), microglial activation, yeast, vitamin A deficiency, microbial imbalances, viral load, retained primitive reflexes
- Vocal Stimming: excess glutamate (specifically around the vagus nerve), microglial activation, yeast, high inflammation, viral load, microbial imbalances, low magnesium
Movement Disorders/Stimming/CMS/Repetitive Behavior’s: excess glutamate (especially around the vagus nerve), microglial activation, low GABA, yeast, high inflammation, GI inflammation, microbial imbalances, phenols, viral load, low magnesium see sensory seeking, PANS, PANDAS
- Constipation: excess glutamate/low GABA, SIBO, mitochondrial dysfunction, low magnesium microbial imbalances, blockage, dehydration, dairy, too many nuts and/or bananas
- Diarrhea: GI inflammation, microbial imbalances, food allergies, food sensitivities, blockage, histamine, mast cell activation, CFD
- Undigested Food in Stool: malabsorption, lack of enzymes, bile production, GI inflammation, food intolerances/fast transit, microbial imbalances, yeast
- Floating Stool: fat malabsorption, malabsorption
- Sand like Gritty Stool: oxalate dumping
- Very Smelly: constipation, die-off, microbial imbalances, clostridia
- Green in Color: diet high in greens, bile production, microbial imbalances, antibiotics/probiotics, fast transit time
- Pale or Yellow in Color: liver congestion, bile production, fat malabsorption, parasites, microbial imbalances, GI inflammation, coconut flour, fast transit time
- Red in Color: Beet consumption, ulcers, bleeding in the GI tract, GI inflammation, hemorrhoids
Sweating (particularly at night): Detox, Babesia
Tics: excess glutamate, microglial activation, GI inflammation, microbial imbalances (bacteria), low magnesium, EMF exposure, screen time, PANS, PANDAS
Toe Walking: excess glutamate, yeast, GI inflammation, retained primitive reflexes
Wet the bed/pants: excess glutamate, detox, low magnesium, PANS, PANDAS
W-Sitting: low tone, excess glutamate, mitochondrial dysfunction, need for carnitine see sensory seeking, retained primitive reflexes
Yes/No Loop: excess glutamate
Early on in our journey, our Integrative Pediatrician suggested that we try MNRI® or reflex integration therapy. Not being too familiar with it, we held off for three years and proceeded forward with the more traditional therapies, speech therapy, occupational therapy and physical therapy. MNRI® stands for Masgutova Neurosensorimotor Reflex Integration where they use a set of physical patterns to integrate any primitive reflexes that may have been retained. The therapy itself is very hands-on, similar to physical or massage therapy, where the practitioner helps to assist the body through physical patterns that typically occur during natural development. These developmental patterns are often as familiar as crawling or developing a proper grasp but make a significant neurological impact. If the body has some amount of substantial stress, some of these reflexes are unable to integrate properly, which can lead to holes in development. Read More
Early on while working with our integrative pediatrician on dietary changes and the incorporation of a handful of supplements (which we’ve since discontinued), we noticed that our sons eczema drastically increased. What were once small little dime sized rough spots on his skin, grew into an angry head to toe rash covering most of his body.
Assuming it was something his skin was coming into contact with, I overhauled household items he was frequently exposed to – cleansers, detergents, fragrances, switched to organic cotton, etc. and he was still inflamed. Read More
We clearly knew that food was a big factor for our son, so not long after we started removing sources of glutamate, we decided to do some food sensitivity testing. While there are many different food sensitivity testing options, our integrative pediatrician suggested we try the Alletess IgG Food Sensitivity panel. IgG sensitivity panels test for IgG (immunoglobulin G) antibody levels (opposed to IgE- true allergy) to a variety of foods. Read More