This is a powerful immune stimulator for anti-viral immunity and it powerfully inhibits the cytokine storm.

Most immune stimulators activate the microglia. When this is done frequently, the microglia can be chronically activated, resulting in an outpouring of inflammatory cytokines and glutamate. There have been studies examining the TNF-α cytokine which is typically increased with immune stimulators, but astragalus, in particular, DECREASES TNF-α cytokines. I cannot tell you exactly why this happens, but there have been a few studies indicating that it does.

Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427284/

It has been suggested that those with chronic underlying infections, an autoimmune disease, pregnant and or nursing women should not use astragalus root.

Why Is This Important?

Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters; dopamine, serotonin, and GABA are great examples. When glutamate is in excess, it is extremely toxic to the brain and nervous system. It can become so excitatory. It is considered an excitotoxin, which means that it overstimulates brain cells to the point of killing them or damaging them enough to cause severe mitochondrial dysfunction (associated with low muscle tone) and neurological inflammation. Excess glutamate is believed to be involved in a variety of neurological and neurodegenerative disorders, including autism, obsessive-compulsive disorders, hyperactivity disorders, complex motor stereotypes, tics, insomnia, anxiety disorders, seizures, sensory processing disorder, addiction, depression, chronic fatigue, PANS, PANDAS, Alzheimer’s, and so on. Excess glutamate also impairs methylation and depletes glutathione levels vital for detoxification, controlling inflammation, and gut health.  Working to lower glutamate/inflammation and balance GABA is key to improving overall health.

Obviously, diet (REID) is one of the most important, if not the most important, step in lowering glutamate. However, this natural option may prove beneficial in helping when experiencing a peak of symptoms related to high glutamate and neurological inflammation, i.e., following consumption of a high glutamate food, trauma or a “flare” from PANS (pediatric autoimmune neuropsychiatric disorder) or PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections).  Additionally, working to lower inflammation/glutamate by treating underlying inflammation sources (metals, microbial imbalances, parasites, microglial activation, poor detoxification pathways, various toxins, etc.) will also be hugely beneficial.  We’ve personally found homeopathy to be great for this.

I do not have personal experience with all options mentioned on the “Lowering Glutamate” page, nor would I recommend all of them (especially the pharmaceutical options). You will want to read the comments as some of the items used to lower glutamate temporarily can actually work to increase glutamate/glutamate sensitivity over time.

The information shared within this blog has been gathered by a mother, not a physician, and should not act as medical advice. Under no circumstances shall I, or any contributors and affiliates of the blog, be responsible for damages arising from the blog’s use.