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Lowering Glutamate | Lithium Orotate

In this post, we are referring to the low-dose mineral supplement, Lithium Orotate,  and not the high-dose prescription, Lithium Carbonate, which is known to have many side effects. Again, this is not considered medical advice and dosing/exposure will depend on individual needs. "Lithium is thought to help regulate the neurotransmitter glutamate by keeping the amount of glutamate between brain cells at a stable, healthy level to support healthy brain function. The mineral has been shown to be neuroprotective and to prevent neuronal cell death from free radical stress, effectively protecting neurons from glutamate-induced, NMDA receptor-mediated free [...]

Lowering Glutamate | Lithium Orotate2022-09-22T12:52:27-04:00

Lowering Glutamate | Astragalus Root

This is a powerful immune stimulator for anti-viral immunity and it powerfully inhibits the cytokine storm. Most immune stimulators activate the microglia. When this is done frequently, the microglia can be chronically activated, resulting in an outpouring of inflammatory cytokines and glutamate. There have been studies examining the TNF-α cytokine which is typically increased with immune stimulators, but astragalus, in particular, DECREASES TNF-α cytokines. I cannot tell you exactly why this happens, but there have been a few studies indicating that it does. Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427284/ It [...]

Lowering Glutamate | Astragalus Root2021-09-16T11:57:25-04:00

Lowering Glutamate | Cistus

Our family LOVES to hike and can be found wandering in the woods during most of the summer.  After a bullseye rash and Lyme scare a few years ago, I started incorporating the herb Cistus prior to hiking as it is known to repel ticks.  This mild and sweet-tasting herb was an easy addition to our herbal teas but wasn’t until recently that I discovered the true benefits of this incredible herb. Sardinian Cistus Incanus has a long list of healing properties, but is most well known for its anti-bacterial, anti-mold, anti-viral (Lyme, herpes, EBV, HIV, etc) properties [...]

Lowering Glutamate | Cistus2021-09-16T12:11:45-04:00

Lowering Glutamate | Flaxseed Oil

"Monosodium glutamate (MSG) is immensely globally used as a food aroma and additive, several studies indicated its toxicity in different body organs. Here, we aimed to evaluate brain dysfunctions in experimental animal that administered MSG and appreciate the beneficial role of flaxseed oil in attenuating this effect." "The results of this study indicated that MSG was responsible for brain dysfunction that appeared in disturbances of neurotransmitters levels. In addition , the administration of omega-3 fatty acids in treated group effectively attenuated this dysfunctions through replacing omega-6 fatty acids in the neurocells by omega-3 fatty acids that [...]

Lowering Glutamate | Flaxseed Oil2021-09-16T12:19:00-04:00

Lowering Glutamate | Mitochondrial Supports

Mitochondrial Supports CoQ10, L-Carnitine, ALA– “Increasing energy production, using coenzyme Q-10,, L-carnitine, alpha-lipoic acid, and other metabolic precursors and substrates can significantly reduce glutamate excitotoxic damage”  http://www.encognitive.com/…/A%20POSSIBLE%20CENTRAL… Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters, dopamine, serotonin and GABA are great examples. When glutamate is in excess it is extremely toxic [...]

Lowering Glutamate | Mitochondrial Supports2021-09-16T12:24:51-04:00

Lowering Glutamate | Milk Thistle

Milk Thistle (contains flavonoid, silymarin)– inhibits microglial activation. “Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation” .https://www.ncbi.nlm.nih.gov/pubmed/12473078 "In conclusion, it was conducted that there were toxic effects of MSG on male rabbits through increase the damage in the liver and Kidney and oxidative stress through elevation in ALT, AST enzymes, creatinine and cholesterol. Also, with adding Silymarin daily in a dose of (1.2mg/100g BW) showed ameliorative Impact of (Silymarin) on Monosodium Glutamate Toxicity" HEMATOLOGICAL STUDY OF SILYMARIN ON MONOSODIUM GLUTAMATE TOXICITY IN RABBITS http://www.plantarchives.org/SPL%20ISSUE%2020-2/1__1-6_.pdf OTHER BENEFITS Anti-inflammatory Antioxidant Can help with glutathione production Improves [...]

Lowering Glutamate | Milk Thistle2021-09-16T12:26:13-04:00

Lowering Glutamate | B8 (Inositol)

Vitamin B8 (Inositol)- found in brown rice, organ meats, citrus, nuts, and leafy greens. Inositol (B8) is key in excess glutamate break down… “As a nootropic, Vitamin B8 (Inositol) can be used to treat panic attacks and anxiety, depression, Obsessive Compulsive Disorder (OCD), bulimia, depression in bipolar disorder and mood swings.” https://nootropicsexpert.com/vitamin-b8-inositol/ Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate [...]

Lowering Glutamate | B8 (Inositol)2021-09-16T12:27:11-04:00

Lowering Glutamate | B12

Vitamin B12- found in beef, liver, chicken, clams, and tuna. “Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Chronic administration of methylcobalamin protects cultured retinal neurons against N-methyl-D-aspartate-receptor-mediated glutamate neurotoxicity, probably by altering the membrane properties through SAM-mediated methylation.” https://www.ncbi.nlm.nih.gov/pubmed/9112980 “Vitamin B12 enhances GABA content but reduces glutamate content in the rat suprachiasmatic nucleus.” https://www.ncbi.nlm.nih.gov/pubmed/9249572 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or [...]

Lowering Glutamate | B122021-09-16T12:27:52-04:00

Lowering Glutamate | Vitamin C

Vitamin C- Vitamin C is intertwined with glutamate signaling and glutamate release. It has the ability to neutralize free radicals, reduce oxidative stress, improve mitochondrial function, and offer protection during glutamate release. The use of whole food sources such as rose hips, Camu Camu, guava, kiwi, strawberry, cherry, blackberry, blueberry, raspberry, beet, carrot, spinach, broccoli, kale, cabbage, parsley, brussel sprouts, ginger, cauliflower, cranberries, asparagus, etc. are much preferred over supplementation in my opinion (glutamate risk and may contribute to oxalate issues). “Vitamin C also has antioxidant properties that may prove to be helpful in treating HD. [...]

Lowering Glutamate | Vitamin C2021-09-16T12:29:42-04:00

Lowering Glutamate | Zinc

Zinc-  It is important to note that zinc and copper need to be in balance and supplementing with one can disrupt this balance. New study presents a working model that could point to a better understanding of autism’s underpinnings. “The new study, led by Stanford neuroscientists John Huguenard, PhD, and Sally Kim, PhD, and then-graduate student Huong Ha, PhD, showed that zinc is required for the proper behavior of two related proteins, Shank 2 and Shank 3, that hang out at most synapses in the brain. Among their duties, Shank 2 and Shank 3 can reshuffle [...]

Lowering Glutamate | Zinc2021-09-16T12:37:46-04:00
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