Lowering Glutamate

Lowering Glutamate | Taurine

Lowering Glutamate | Taurine

Taurine–Is an inhibitory amino acid. Beef, lamb, dark chicken meat, and eggs are food sources of taurine. Why is taurine from whole food important? Commercial taurine supplements can increase sulfur which may already be high due to certain gene mutations (CBS & SUOX), and supplementing any free amino acid can pose some amount of glutamate risk. Additionally, the toxins associated with yeast/candida (which is very common) can deplete taurine. Since taurine is so important in the conversion of glutamate to GABA and as an inhibitory neurotransmitter, it is important that adequate levels are achieved through diet. [...]

Lowering Glutamate | Taurineandistowe2024-08-24T19:09:56-04:00

Lowering Glutamate | Sulforaphane

Lowering Glutamate | Sulforaphane

Sulforaphane- Found highest in broccoli sprouts/microgreens (can often be found at your local health food store by the lettuce), followed by broccoli, cauliflower, kale, brussel sprouts, cabbage, bok choy and collard greens. Remember that good old study, linking improvements in autism symptoms to broccoli sprout extract/sulforaphane? One of the major mechanisms in this process, is that sulforaphane is neuroprotective against excess glutamate/excitotoxicity. Time to start adding the sprouts/microgreens to your meals! “Many parents and caregivers articulated the positive effects of SF, both during the intervention phase and in the ensuing 3 years reported herein. These observations [...]

Lowering Glutamate | Sulforaphaneandistowe2024-08-24T19:09:05-04:00

Lowering Glutamate | Selenium

Lowering Glutamate | Selenium

Selenium- One brazil nut per day should give you the daily recommended amount of selenium needed. “These results suggest that glutamate targets the mitochondria and selenium supplementation within physiological concentration is capable of preventing the detrimental effects of glutamate on the mitochondria” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378533/42

Lowering Glutamate | Seleniumandistowe2024-08-24T19:08:09-04:00

Lowering Glutamate | Resveratrol

Lowering Glutamate | Resveratrol

Resveratrol– found in red grapes, red wine, blueberries, peanuts and dark chocolate, calms microglial activation. “Resveratrol reduced glutamate-induced damages” “Resveratrol interacts with the complex III of the respiratory chain, is a radical scavenger and also suppressor of radical formation in the mitochondria. It reduces the intracellular calcium levels in pre- and postsynaptic neurons and also may inhibit the pro-apoptotic factors in glutamate overflow that occurs, e.g. in excitotoxicity. In cell cultures, glutamate overflow leads to formation of free radicals and results in apoptosis.” https://www.ncbi.nlm.nih.gov/pubmed/23459926 “Our findings reinforce the protective role of this compound in some brain disorders, [...]

Lowering Glutamate | Resveratrolandistowe2024-08-24T19:07:40-04:00

Lowering Glutamate | Red Sage (Dan Shen)

Lowering Glutamate | Red Sage (Dan Shen)

Red Sage/Dan Shen– Red sage aka dan shen, inhibits glutamate release. “These results show that tanshinone IIA inhibits glutamate release from cortical synaptosomes in rats through the suppression of presynaptic voltage-dependent Ca(2+) entry and MEK signaling cascade” https://www.ncbi.nlm.nih.gov/pubmed/23542145

Lowering Glutamate | Red Sage (Dan Shen)andistowe2024-08-24T19:06:58-04:00

Lowering Glutamate | Qing Brick Tea

Lowering Glutamate | Qing Brick Tea

Qing Brick Tea– Our results showed that QBT intake was effective in protecting monosodium glutamate-induced obese mice against metabolic syndrome and involved in the Nrf2 signaling pathway in the skeletal muscle.” https://www.sciencedirect.com/science/article/abs/pii/S0753332217362029

Lowering Glutamate | Qing Brick Teaandistowe2024-08-24T19:05:47-04:00

Lowering Glutamate | Quercetin Flavonoid

Lowering Glutamate | Quercetin Flavonoid

Quercetin- Inhibits glutamate release and is found in onion (highest in red onion), raw chili peppers, asparagus, kale, berries, plums, peppers, broccoli, sophora japonica leaf/flowers. However, we have also used this supplement. “These results suggest that quercetin inhibits glutamate release from rat cortical synaptosomes and this effect is linked to a decrease in presynaptic voltage-dependent Ca(2+) entry and to the suppression of PKC and PKA activity.” https://www.ncbi.nlm.nih.gov/pubmed/23933436 Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death “This is the first report on the detailed mechanisms of the protective effect of quercetin on HT22 cells. Onion extract [...]

Lowering Glutamate | Quercetin Flavonoidandistowe2024-08-24T19:06:14-04:00

Lowering Glutamate | Pyrroloquinoline Quinone (PQQ)

Lowering Glutamate | Pyrroloquinoline Quinone (PQQ)

Pyrroloquinoline quinone (PQQ)- Widely found in bacteria and foods such as spinach, celery, parsley, kiwi papaya and beans. It is known to stimulate the production and efficiency of mitochondria, protects against free radicals and reduces nitric oxide production. Defiencies in PQQ are associated with immune deficiency, dry skin, infertility and low overall fitness. “our results indicated that PQQ could protect primary cultured hippocampal neurons against glutamate-induced cell damage by scavenging ROS, reducing Ca2+ influx, and caspase-3 activity, and suggested that PQQ-activated PI3K/Akt signaling might be responsible for its neuroprotective action through modulation of glutamate-induced imbalance between Bcl-2 [...]

Lowering Glutamate | Pyrroloquinoline Quinone (PQQ)andistowe2024-08-24T19:05:22-04:00

Lowering Glutamate | Pomegranate

Lowering Glutamate | Pomegranate

Pomegranate- “Neuroprotective effects of pomegranate effects are reducing accumulations of amyloid plaques in hippocampus, preventing neuronal tissue loss, modulating GABA and glutamate levels, inhibiting acetylcholine esterase and inhibiting lipid peroxidation in brain.” A comprehensive review of the neuroprotective effects of pomegranate.

Lowering Glutamate | Pomegranateandistowe2024-08-24T19:04:40-04:00

Lowering Glutamate | Narigenin Flavonoid

Lowering Glutamate | Narigenin Flavonoid

Naringenin Flavonoid (found in citrus, grapes, etc.)- ” Furthermore, naringenin induced the brain-derived neurotrophic factor and other neuroprotective cytokines, and markedly improved the survival rates of the neurons 24 h following glutamate exposure. The observed results suggest that the naturally occurring bioflavonoid (naringenin) exerts neuroprotective effects via highly specific molecular targets in neurons.” Protective effect of naringenin on glutamate-induced neurotoxicity in cultured…. Available from:https://www.researchgate.net/publication/276868364_Protective_effect_of_naringenin_on_glutamate-induced_neurotoxicity_in_cultured_hippocampal_cells “There was significant recovery of glutathione content and all the antioxidant enzymes studied. Also in case of behavioural parameters studied, naringenin showed decrease in seizure severity. All these changes were supported by histological [...]

Lowering Glutamate | Narigenin Flavonoidandistowe2024-08-24T19:01:40-04:00