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Lowering Glutamate | Moringa

Moringa and Glutamate Moringa has shown to help mitigate the damages of dietary monosodium glutamate by modifying liver function, oxidative stress, DNA damage, kidney injury, liver injury, and PCNA expression. Roles of Moringa oleifera Leaf Extract in Improving the Impact of High Dietary Intake of Monosodium Glutamate-Induced Liver Toxicity, Oxidative Stress, Genotoxicity, DNA Damage, and PCNA Alterations in Male Rats https://www.hindawi.com/journals/omcl/2018/4501097/ "Monosodium glutamate (MSG) produces adverse and damaging effects in different organs like liver and kidneys. Moringa causes ameliorating effect on kidney and liver injury induced by monosodium glutamate in rats."  Ameliorating Effect of Moringa against Liver and [...]

Lowering Glutamate | Moringa2021-09-16T13:12:16-04:00

Lowering Glutamate | Passion Flower

Passion Flower- is known to increase levels of GABA in the brain, calm, decrease anxiety, improve sleep, improve liver function, and help to recover from adrenal fatigue. "The properties in passionflower are thought to promote calming effects by increasing the levels of the chemical gamma-aminobutyric acid (GABA), which reduces the activity of some neurons that cause anxiety." https://www.drweil.com/vitamins-supplements-herbs/herbs/passionflower/ "Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941540/ "Passionflower (Passiflora incarnata) was used traditionally in the Americas and later in Europe as a calming herb for [...]

Lowering Glutamate | Passion Flower2021-09-16T13:15:27-04:00

Lowering Glutamate | Honokiol (Magnolia Bark)

Honokiol (connected to magnolol) also known as Magnolia Bark Extract , is rapidly gaining in popularity due to its ability to help relive the symptoms many aliments associated with excess glutamate.  Honokiol helps to convert excess glutamate into GABA. While it is primarily known to help combat cancer, inflammation, depression, sleep disturbances, EBV, Lyme and manage pain, it also carries quite a few risks, especially when recreationally misused.  Please do your own research and consult with your medical provider before starting this one as it impacts benzodiazepine sites. This is just a brief overview of what [...]

Lowering Glutamate | Honokiol (Magnolia Bark)2021-09-16T13:16:33-04:00

Lowering Glutamate | Melatonin

Melatonin-  Melatonin is often just associated with sleep and there is a huge connection between sleep disturbances and an imbalance in glutamate (excites) and GABA (calms). Our children lean towards excess glutamate which will make them more prone to sleep disturbances. The smallest amount of glutamate would wake my son for 2-3 nights. Melatonin and glutamate have a complicated relationship.  It appears as though melatonin protects against excess glutamate AND glutamate inhibits melatonin (fluoride and aspartate/aspartame do as well). Some Foods/Herbs Highest in Melatonin Tart cherries Asparagus Walnuts Almonds Pomegranate Raspberries Broccoli Cucumber Mustard seeds Fenugreek [...]

Lowering Glutamate | Melatonin2021-09-16T13:17:23-04:00

Lowering Glutamate | Magnesium

Magnesium- In our experience, magnesium has made the most significant impact in reducing our symptoms within a flare. Magnesium protects against glutamate damage, sits on the NMDA glutamate receptor, calms cells, helps to raise GABA, improves motility, is a potent antioxidant, increases glutathione, and can help to resolve many various health issues. It is also my understanding that one will quickly burn through magnesium due to neuron firing when in an excitotoxic state (or a flare). Low magnesium is also associated with oxidative stress and a significant fall in cellular glutathione, low vitamin D, and a dramatic [...]

Lowering Glutamate | Magnesium2023-04-04T12:40:57-04:00

Lowering Glutamate | Luteolin Flavonoid

Luteolin- A type of flavonoid found in celery, chamomile, carrots, celery, parsley, thyme, oregano, sage, basil, peppermint, artichoke and spinach is known to reduce brain and systematic inflammation by CALMING MICROGLIAL CELLS and therefore lower glutamate and cytokine levels (microglia are activated as a first step in immune response and they signal additional glutamate). Mixing these food sources with coconut oil or olive oil will help increase absorption. It is also a strong inhibitor of mast cells and helps autoimmune disorders with the reduction of immune cells. Luteolin has also been shown to stimulate brain repair, reduce exitotoxicity (from [...]

Lowering Glutamate | Luteolin Flavonoid2021-09-16T13:27:06-04:00

Lowering Glutamate | Lion’s Mane

Lion’s Mane– Reduces neuronal excitability from glutamate “Extract suppressed the excitation of neurons caused by L-glutamic acid application. The assumption is made that the H. erinaceus extract contains substances that may activate receptors that cause an inhibition of spike activity. The inhibitory effect of extract was not induced by GABA and serotonin receptor activation or activation of M- and N-cholinoreceptors. Inhibition of spike activity was caused by hyperpolarization of the neuronal membrane during extract application.” http://www.dl.begellhouse.com/journals/708ae68d64b17c52,0d49dda96a2a7147,504922782f5fa5ea.html Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous [...]

Lowering Glutamate | Lion’s Mane2021-09-16T13:29:43-04:00

Lowering Glutamate | Licorice Root (Glycyrrhizin)

Licorice Root (Glycyrrhizin) high in Carbenoxolone – inhibits glutamate release from microglia! “Liquiritigenin effectively reduced glutamate-induced early apoptosis through inhibition of Ca(2+) influx, intracellular reactive oxygen species (ROS) production, and lipid peroxidation.” https://www.ncbi.nlm.nih.gov/pubmed/24012889  “These observations suggest that glycyrrhizic acid may be of therapeutic value for the prevention of cerebral damage elicited by the glutamate.” http://europepmc.org/abstract/med/16952351 Thus, blockade of glutamate release from activated microglia with CBX or DON may be an effective therapeutic strategy against neurodegeneration in MS. https://www.ncbi.nlm.nih.gov/pubmed/19212100  Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous [...]

Lowering Glutamate | Licorice Root (Glycyrrhizin)2021-09-16T13:31:06-04:00

Lowering Glutamate | Lemon Balm

Lemon Balm (Melissa officinalis L)- increases GABA which helps lower glutamate and establish balance between the two neurotransmitters. “These results suggest that MOE increases cell proliferation, neuroblast differentiation and integration into granule cells by decreasing serum corticosterone levels as well as by increasing GABA levels in the mouse DG.” https://www.ncbi.nlm.nih.gov/pubmed/21076869 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has [...]

Lowering Glutamate | Lemon Balm2021-09-16T13:32:04-04:00

Lowering Glutamate | Lavender

Lavender- protects against glutamate induced neurotoxicity Inhalation of lavender was also noted to inhibit convulsion induced by pentylenetetrazol, nicotine, or electroshock in mice [33]. Linalool, one of the major components of lavender oil, has been shown to inhibit the convulsion induced by pentylenetetrazol and transcorneal electroshock in different animal models [34, 35], an effect that may induce via a direct interaction with the glutamatergic NMDA subreceptor as well as GABAA receptors [36]. The neuroprotective effect of lavender oil on cerebral ischemia/reperfusion injury was investigated in mice. Focal cerebral ischemia was induced by the intraluminal occlusion. An aqueous extract [...]

Lowering Glutamate | Lavender2021-09-16T13:34:24-04:00
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