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Lowering Glutamate | Kudzu (Puerarin)

Kudzu (aka Puerarin)– If you've driven along the highway in the south, you've likely noticed this highly invasive Japanese vine covering nearly everything. From billboards to abandoned buildings, it is everywhere!  In fact, my husband has battled it for so long, that he refers to himself as the Kudzu King, complete with his own pair of "Kudzu King" coveralls.  It wasn't until our journey with our son, that I started to develop a better appreciation for this plant. Kuduz is actually neuroprotective against glutamate! Neuroprotective Effect of Puerarin on Glutamate-Induced Cytotoxicity in Differentiated Y-79 Cells via [...]

Lowering Glutamate | Kudzu (Puerarin)2021-09-16T13:35:27-04:00

Lowering Glutamate | Hesperidin Flavonoid

Hesperidin Flavonoid (found in citrus peel)- neuroprotective against glutamate excitotoxicity. “The citrus flavonoid hesperidin exerts neuroprotective effects and could cross the blood-brain barrier. Given the involvement of glutamate neurotoxicity in the pathogenesis of neurodegenerative disorders, this study was conducted to evaluate the potential role of hesperidin in glutamate release and glutamate neurotoxicity in the hippocampus of rats.)””These results demonstrate that hesperidin inhibits evoked glutamate release in vitro and attenuates in vivo KA-induced neuronal death in the hippocampus. Our findings indicate that hesperidin may be a promising candidate for preventing or treating glutamate excitotoxicity related brain disorders [...]

Lowering Glutamate | Hesperidin Flavonoid2021-09-16T13:36:23-04:00

Lowering Glutamate | Grape Seed Extract

Grape Seed extract– is a popular antioxidant and inhibits glutamate induced cell death. “Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons.” “All these data suggest that GSPE inhibits 0.1 mM [Mg²⁺]o- and oxygen glucose deprivation-induced neurotoxicity through inhibition of calcium signals and NO formation in cultured rat hippocampal neurons.” https://www.ncbi.nlm.nih.gov/pubmed/21810275 “Polyphenols extracted from grape seeds are able to inhibit amyloid-beta (Abeta) aggregation, reduce Abeta production and protect against Abeta neurotoxicity in vitro.” “Amyloid plaques and microgliosis in the brain of Alzheimer’s mice fed with [...]

Lowering Glutamate | Grape Seed Extract2021-09-16T13:37:19-04:00

Lowering Glutamate | Ginseng

Ginseng– inhibits inflammation caused by microglial/immune activation and therefore lower glutamate and cytokine levels (microglia are activated as a first step in immune response and they signal additional glutamate/cytokines/etc). “Ginseng extracts also inhibit immunoexcitotoxic activation of microglia, an important factor in preventing the destructive process of Alzheimer’s disease. In fact, components in American ginseng, Korean red ginseng, and Panax ginseng all inhibit inflammation caused by microglial activation. Regulation of microglial activity is critically important in brain protection because these specialized immune cells can either be beneficial or quite harmful, depending on what state they are in. The protective activation mode stimulates [...]

Lowering Glutamate | Ginseng2021-09-16T13:37:57-04:00

Lowering Glutamate | Ginko Biloba

Gingko biloba- Neuroprotective effects of Ginkgo biloba extract. “Antagonistic effects of extract from leaves of Ginkgo biloba on glutamate neurotoxicity” https://www.researchgate.net/publication/13217791_Antagonistic_effects_of_extract_from_leaves_of_Ginkgo_biloba_on_glutamate_neurotoxicity “The effects described mostly in animals include those on cerebral blood flow, neurotransmitter systems, cellular redox state and nitric oxide level. https://www.ncbi.nlm.nih.gov/pubmed/14523543 “Molecular evidence of the neuroprotective effect of Ginkgo biloba (EGb761) using bax/bcl-2 ratio after brain ischemia in senescence-accelerated mice, strain prone-8.” https://www.ncbi.nlm.nih.gov/pubmed/16677616 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites [...]

Lowering Glutamate | Ginko Biloba2021-09-21T10:32:49-04:00

Lowering Glutamate | Ginger

Ginger- We try to use fresh ginger root as often as possible.  However, any leftover ginger can be chopped and stored in an airtight container in the freezer for months. “From these results, we can say that the ginger extract has a neuroprotective role against monosodium glutamate toxicity effect.” https://www.ncbi.nlm.nih.gov/pubmed/19579948 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has [...]

Lowering Glutamate | Ginger2021-09-21T10:34:14-04:00

Lowering Glutamate | GABA

GABA (Gamma-Aminobutyric Acid)– I wouldn’t suggest supplementing with GABA.  Many believe that taking GABA can be a quick fix to resolve underlying glutamate problems, but unfortunately this is not the case.  To increase GABA, one must work to lower glutamate and increase beneficial gut bacteria. Sprouted or germinated rice (especially black rice) is often recommended to increase GABA.  The sprouting/germination process increases the naturally occurring levels of GABA, but due to the protein degradation that occurs in this process, it can also increases free glutamate. “GABA itself can be converted back into glutamine, which is then converted back [...]

Lowering Glutamate | GABA2021-09-21T10:35:09-04:00

Lowering Glutamate | Frankincense

Frankincense- While some of these studies are geared towards arthritis, they indicate that frankincense (from the Boswellia genus) can be protective against glutamate, cytokine damage, unregulated calcium and help with neuroinflammation.  It can even help against the spread of cancer.  We personally saw increased speech when we started applying diluted frankincense essential oil to the back of our sons neck before bed. Boswellia serrata Protects Against Glutamate-Induced Oxidative Stress and Apoptosis in PC12 and N2a Cells https://www.ncbi.nlm.nih.gov/pubmed/27494534 Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage http://onlinelibrary.wiley.com/doi/10.1002/ptr.3055/full “The resinous part of Boswellia serrata possesses [...]

Lowering Glutamate | Frankincense2021-09-21T10:36:37-04:00

Lowering Glutamate | Curcumin (Turmeric)

Curcumin (Turmeric) – Protects against glutamate and inhibits glutamate release. “Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB” https://www.ncbi.nlm.nih.gov/pubmed/18420184 “Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network” https://www.hindawi.com/journals/ecam/2015/706207/ “Curcumin Protects against Monosodium Glutamate Neurotoxicity and Decreasing NMDA2B and mGluR5 Expression in Rat Hippocampus.” https://www.ncbi.nlm.nih.gov/pubmed/27529496 “Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK” http://www.sciencedirect.com/science/article/pii/S0041008X15000927 “Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus and reduces fever during LPS-induced systemic inflammation in rabbits” http://www.sciencedirect.com/science/article/pii/S0014299908007449 [...]

Lowering Glutamate | Curcumin (Turmeric)2021-09-21T10:37:55-04:00

Lowering Glutamate | Cysteine

Cysteine-  Reduces excess glutamate. Found in oats, broccoli, red pepper, onion, banana, garlic and will become an antioxidant when converted to glutathione. The body converts the supplement NAC to cysteine. “If you take NAC, you’re giving your body an efficient way to soak up excess glutamate, and reducing oxidative stress and inflammation over time by giving it glutathione. As a result, this helps alleviate a number of different mental health issues.” http://www.optimallivingdynamics.com/blog/the-powerful-antioxidant-proven-to-treat-6-mental-illnesses Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It [...]

Lowering Glutamate | Cysteine2021-09-21T10:39:35-04:00
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