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Lowering Glutamate | B6

Vitamin B6, aka Pyridoxine Vitamin B6 is mainly provided by diet and bacterial synthesis in the gut. All B-Vitamins help to convert food into fuel and are important in energy production. B6 is essential for normal brain development, nervous system regulation, amino acid metabolism, and keeping our immune system functioning well. Vitamin B6 is essential in converting excitatory glutamate into calming GABA. Deficiencies in Vitamin B6 alone can contribute to a build-up of excess glutamate, resulting in symptoms. In a recent study, it has been proposed that Vitamin B6 can help repair the GABA system. Therefore, [...]

Lowering Glutamate | B62023-05-17T21:50:01-04:00

Lowering Glutamate | Taurine

Taurine–Is an inhibitory amino acid. Beef, lamb, dark chicken meat, and eggs are food sources of taurine. Why is taurine from whole food important? Commercial taurine supplements can increase sulfur which may already be high due to certain gene mutations (CBS & SUOX), and supplementing any free amino acid can pose some amount of glutamate risk. Additionally, the toxins associated with yeast/candida (which is very common) can deplete taurine.  Since taurine is so important in the conversion of glutamate to GABA and as an inhibitory neurotransmitter, it is important that adequate levels are achieved through diet. [...]

Lowering Glutamate | Taurine2023-06-28T11:39:12-04:00

Lowering Glutamate | Sulforaphane

Sulforaphane- Found highest in broccoli sprouts/microgreens (can often be found at your local health food store by the lettuce), followed by broccoli, cauliflower, kale, brussel sprouts, cabbage, bok choy and collard greens.  Remember that good old study, linking improvements in autism symptoms to broccoli sprout extract/sulforaphane?  One of the major mechanisms in this process, is that sulforaphane is neuroprotective against excess glutamate/excitotoxicity. Time to start adding the sprouts/microgreens to your meals! “Many parents and caregivers articulated the positive effects of SF, both during the intervention phase and in the ensuing 3 years reported herein. These observations [...]

Lowering Glutamate | Sulforaphane2021-09-16T13:01:14-04:00

Lowering Glutamate | Selenium

Selenium- One brazil nut per day should give you the daily recommended amount of selenium needed. “These results suggest that glutamate targets the mitochondria and selenium supplementation within physiological concentration is capable of preventing the detrimental effects of glutamate on the mitochondria” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378533/42 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters, [...]

Lowering Glutamate | Selenium2021-09-16T13:02:17-04:00

Lowering Glutamate | Resveratrol

Resveratrol– found in red grapes, red wine, blueberries, peanuts and dark chocolate, calms microglial activation. “Resveratrol reduced glutamate-induced damages” “Resveratrol interacts with the complex III of the respiratory chain, is a radical scavenger and also suppressor of radical formation in the mitochondria. It reduces the intracellular calcium levels in pre- and postsynaptic neurons and also may inhibit the pro-apoptotic factors in glutamate overflow that occurs, e.g. in excitotoxicity. In cell cultures, glutamate overflow leads to formation of free radicals and results in apoptosis.” https://www.ncbi.nlm.nih.gov/pubmed/23459926 “Our findings reinforce the protective role of this compound in some brain disorders, [...]

Lowering Glutamate | Resveratrol2021-09-16T13:03:16-04:00

Lowering Glutamate | Qing Brick Tea

Qing Brick Tea– Our results showed that QBT intake was effective in protecting monosodium glutamate-induced obese mice against metabolic syndrome and involved in the Nrf2 signaling pathway in the skeletal muscle.” https://www.sciencedirect.com/science/article/abs/pii/S0753332217362029 Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It is classified as an excitatory neurotransmitter, which means it excites or stimulates nerve cells located throughout the nervous system. Glutamate also has the ability to regulate other neurotransmitters, dopamine, serotonin and GABA are great examples. When glutamate is in excess [...]

Lowering Glutamate | Qing Brick Tea2021-09-16T13:05:12-04:00

Lowering Glutamate | Quercetin Flavonoid

Quercetin- Inhibits glutamate release and is found in onion (highest in red onion), raw chili peppers, asparagus, kale, berries, plums, peppers, broccoli, sophora japonica leaf/flowers. However, we have also used this supplement. “These results suggest that quercetin inhibits glutamate release from rat cortical synaptosomes and this effect is linked to a decrease in presynaptic voltage-dependent Ca(2+) entry and to the suppression of PKC and PKA activity.” https://www.ncbi.nlm.nih.gov/pubmed/23933436 Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death “This is the first report on the detailed mechanisms of the protective effect of quercetin on HT22 cells. Onion extract [...]

Lowering Glutamate | Quercetin Flavonoid2023-09-22T12:09:41-04:00

Lowering Glutamate | Passion Flower

Passion Flower- is known to increase levels of GABA in the brain, calm, decrease anxiety, improve sleep, improve liver function, and help to recover from adrenal fatigue. "The properties in passionflower are thought to promote calming effects by increasing the levels of the chemical gamma-aminobutyric acid (GABA), which reduces the activity of some neurons that cause anxiety." https://www.drweil.com/vitamins-supplements-herbs/herbs/passionflower/ "Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941540/ "Passionflower (Passiflora incarnata) was used traditionally in the Americas and later in Europe as a calming herb for [...]

Lowering Glutamate | Passion Flower2021-09-16T13:15:27-04:00

Lowering Glutamate | Honokiol (Magnolia Bark)

Honokiol (connected to magnolol) also known as Magnolia Bark Extract , is rapidly gaining in popularity due to its ability to help relive the symptoms many aliments associated with excess glutamate.  Honokiol helps to convert excess glutamate into GABA. While it is primarily known to help combat cancer, inflammation, depression, sleep disturbances, EBV, Lyme and manage pain, it also carries quite a few risks, especially when recreationally misused.  Please do your own research and consult with your medical provider before starting this one as it impacts benzodiazepine sites. This is just a brief overview of what [...]

Lowering Glutamate | Honokiol (Magnolia Bark)2021-09-16T13:16:33-04:00

Lowering Glutamate | Ginseng

Ginseng– inhibits inflammation caused by microglial/immune activation and therefore lower glutamate and cytokine levels (microglia are activated as a first step in immune response and they signal additional glutamate/cytokines/etc). “Ginseng extracts also inhibit immunoexcitotoxic activation of microglia, an important factor in preventing the destructive process of Alzheimer’s disease. In fact, components in American ginseng, Korean red ginseng, and Panax ginseng all inhibit inflammation caused by microglial activation. Regulation of microglial activity is critically important in brain protection because these specialized immune cells can either be beneficial or quite harmful, depending on what state they are in. The protective activation mode stimulates [...]

Lowering Glutamate | Ginseng2021-09-16T13:37:57-04:00
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