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Lowering Glutamate | Cysteine

Cysteine-  Reduces excess glutamate. Found in oats, broccoli, red pepper, onion, banana, garlic and will become an antioxidant when converted to glutathione. The body converts the supplement NAC to cysteine. “If you take NAC, you’re giving your body an efficient way to soak up excess glutamate, and reducing oxidative stress and inflammation over time by giving it glutathione. As a result, this helps alleviate a number of different mental health issues.” http://www.optimallivingdynamics.com/blog/the-powerful-antioxidant-proven-to-treat-6-mental-illnesses Why Is This Important? Glutamate is also the most abundant neurotransmitter, responsible for regulating over 50% of the nervous system. It [...]

Lowering Glutamate | Cysteine2021-09-21T10:39:35-04:00

Lowering Glutamate | Chinese Skullcap (Scutellaria Baicalensis)

Chinese Skullcap (Scutellaria Baicalensis)– neuroprotective against glutamate damage/metabolizes glutamate. “Thus, S.B. extract exhibited neuroprotection against excitotoxic cell death, and this neuroprotection was mediated through the inhibition of NMDA receptor function by interacting with the glycine binding site of the NMDA receptor.” https://www.hindawi.com/journals/tswj/2014/459549/ “Baicalein, a Constituent of Scutellaria baicalensis, Reduces Glutamate Release and Protects Neuronal Cell Against Kainic Acid-Induced Excitotoxicity in Rats” “This study is the first to demonstrate that the natural compound baicalein inhibits glutamate release from hippocampal nerve terminals, and executes a protective action against kainic acid-induced excitotoxicity in vivo. The findings enhance the understanding of [...]

Lowering Glutamate | Chinese Skullcap (Scutellaria Baicalensis)2021-09-21T10:41:06-04:00

Lowering Glutamate | Chinese Club Moss

Chinese Club Moss (Lycopodii Serrati) of the lycopodium family (for those homeopathy followers)– Neuroprotective by blocking the NMDA (a type of glutamate receptor) channels. Only Chinese Club Moss contains Huperzine A which is most commonly known to help with Alzheimers and memory loss. “Thus, on the one hand, HUP-A could be used as a pretreatment against OPs and it might also be a valuable therapeutic intervention in a variety of acute and chronic disorders by protecting against overstimulation of the excitatory amino acid pathway. By blocking NMDA ion channels without psychotomimetic side-effects, HUP-A may protect against [...]

Lowering Glutamate | Chinese Club Moss2021-09-21T10:42:25-04:00

Lowering Glutamate | Cat’s Claw (uncaria tomentosa)

Cat’s Claw (uncaria tomentosa)- NMDA (a type of glutamate receptor) inhibitor.  Should be used with caution as it is a immune system activator and may be problematic for some. “Rhynchophylline and isorhynchophylline are major tetracyclic oxindole alkaloid components of Uncaira species, which have been long used as medicinal plants. In this study, the effects of rhynchophylline and isorhynchophylline on the ionotropic and metabotropic glutamatereceptor-mediated current responses were examined using Xenopus oocytes injected with total RNA prepared from rat cortices or cerebelli.” “hese results suggest that rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncairaspecies [...]

Lowering Glutamate | Cat’s Claw (uncaria tomentosa)2021-09-21T10:43:52-04:00

Lowering Glutamate | Black Cumin Seed

Black Cumin Seed (Nigella Sativa)– We have chosen to use black cumin seed oil to help lower glutamate levels.  I have it  linked in our medicine cabinet. “The secretion of different amino acids was studied in primary cultured cortical neurons by high-performance liquid chromatography (HPLC) using a derivation before injection with dansyl chloride. NS modulated amino acid release in cultured neurons; GABA was significantly increased whereas secretion of glutamate, aspartate, and glycine were decreased. The in vitro findings support the hypothesis that the sedative and depressive effects of NS observed in vivocould be based on changes of inhibitory/excitatory amino acids [...]

Lowering Glutamate | Black Cumin Seed2021-09-21T10:45:10-04:00

Lowering Glutamate | Bergamot Essential Oil

Bergamot Essential Oil–  Neuroprotective and prevents glutamate accumulation “Prevention of Glutamate Accumulation and Upregulation of Phospho-Akt may Account for Neuroprotection Afforded by Bergamot Essential Oil against Brain Injury Induced by Focal Cerebral Ischemia in Rat.” https://www.ncbi.nlm.nih.gov/pubmed/19607983 Bergamot EO possesses a bitter aromatic taste and a characteristic pleasant aroma. It is a popular pharmacopoeias in many countries. It has been also reported for its hypolipemic and hypoglycemics activities, anti-inflammatory, and anti-cancer properties [66,67,68,69,70]. In folk medicine in many countries, it has been popularly used for fever and parasitic diseases. Due to its significant antimicrobial properties, it has been found [...]

Lowering Glutamate | Bergamot Essential Oil2023-06-16T08:26:25-04:00

Lowering Glutamate | Beta-caryophyllene, Copaiba, Cannabis, CBD

Beta-caryophyllene (found in Cannabis, Copaiba Essential Oil, etc) and CBD-  Protects against glutamate. “β-Caryophyllene Protects The C6 Glioma Cells Against Glutamate-Induced Excitotoxicity Through The Nrf2 Pathway.. Available from: https://www.researchgate.net/publication/265393128_b Caryophyllene_Protects_The_C6_Glioma_Cells_Against_Glutamate-Induced_Excitotoxicity_Through_The_Nrf2_Pathway [accessed Oct 26 2017].” https://www.researchgate.net/publication/265393128_b-Caryophyllene_Protects_The_C6_Glioma_Cells_Against_Glutamate-Induced_Excitotoxicity_Through_The_Nrf2_Pathway "Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271072/ Cannabis “Limited research carried out in humans tends to support the evidence that chronic cannabis use reduces levels of glutamate-derived metabolites in both cortical and subcortical brain areas. Research in animals tends to consistently suggest that Δ9-THC depresses glutamate synaptic transmission via CB1 receptor activation, affecting glutamate [...]

Lowering Glutamate | Beta-caryophyllene, Copaiba, Cannabis, CBD2021-09-21T10:49:19-04:00

Lowering Glutamate | Bee Pollen

Update: I've had several questions as to where we've sourced our bee pollen.  While we have historically purchased ours from our local health food store, here is a link for a great organic Amazon option, Greenbow Organic Bee Pollen. Bee Pollen-  There has been a recent article out indicating the neuroprotective benefits of bee pollen on excess glutamate. The article shows that bee pollen effectively reduced the neurotoxic effects of methylmercury by improving neurotransmitter defects, inflammation, apoptosis, and glutamate excitotoxicity.  This study also confirms that mice treated with methylmercury exhibited increased levels of glutamate and low [...]

Lowering Glutamate | Bee Pollen2021-09-22T10:57:21-04:00

Lowering Glutamate | Alpha Lipoic Acid

Alpha Lipoic Acid–  (found in low amounts in spinach, broccoli, yams, etc) ALA is most commonly known a chelating supplement as part of the Andy Cutler Protocol, it is also antioxidant that helps glutamate transport proteins, which aid in the removal of excess extracellular glutamate “Another particularly destructive product is 4-hydroxynonenal (4-HNE), an aldehydic lipid peroxidation product found in abundant supply in cases of neurodegeneration. Interestingly, peroxylnitrite and 4-HNE are found in the same neurons. This lipid peroxidation product has been shown to be especially destructive of synaptic connections and mitochondrial enzymes and can significantly inhibit [...]

Lowering Glutamate | Alpha Lipoic Acid2021-09-22T11:48:13-04:00

Lowering Glutamate | Ashwagandha

Ashwaganda (Withania somnifera)– Protects against glutamate.  Though most commonly known for aiding in adrenal fatigue, this mild herb is protective against glutamate.  We've been able to source it here and most commonly add it to our teas. Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. “ASH-WEX pre-treatment inhibited glutamate-induced cell death and was able to revert glutamate-induced changes in HSP70 to a large extent. Furthermore, the analysis on the neuronal plasticity marker NCAM (Neural cell adhesion molecule) and its polysialylated form, PSA-NCAM revealed that ASH-WEX has therapeutic potential for prevention [...]

Lowering Glutamate | Ashwagandha2021-09-22T11:50:42-04:00
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