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Lowering Glutamate | Black Cumin Seed

Black Cumin Seed (Nigella Sativa)– We have chosen to use black cumin seed oil to help lower glutamate levels.  I have it  linked in our medicine cabinet. “The secretion of different amino acids was studied in primary cultured cortical neurons by high-performance liquid chromatography (HPLC) using a derivation before injection with dansyl chloride. NS modulated amino acid release in cultured neurons; GABA was significantly increased whereas secretion of glutamate, aspartate, and glycine were decreased. The in vitro findings support the hypothesis that the sedative and depressive effects of NS observed in vivocould be based on changes of inhibitory/excitatory amino acids [...]

Lowering Glutamate | Black Cumin Seed2024-08-24T18:33:12-04:00

Lowering Glutamate | Bergamot Essential Oil

Bergamot Essential Oil–  Neuroprotective and prevents glutamate accumulation “Prevention of Glutamate Accumulation and Upregulation of Phospho-Akt may Account for Neuroprotection Afforded by Bergamot Essential Oil against Brain Injury Induced by Focal Cerebral Ischemia in Rat.” https://www.ncbi.nlm.nih.gov/pubmed/19607983 Bergamot EO possesses a bitter aromatic taste and a characteristic pleasant aroma. It is a popular pharmacopoeias in many countries. It has been also reported for its hypolipemic and hypoglycemics activities, anti-inflammatory, and anti-cancer properties [66,67,68,69,70]. In folk medicine in many countries, it has been popularly used for fever and parasitic diseases. Due to its significant antimicrobial properties, it has been found [...]

Lowering Glutamate | Bergamot Essential Oil2024-08-24T18:31:32-04:00

Lowering Glutamate | Berberine Containing Herbs

Berberine (Alkaloid) Containing Herbs (Goldenseal, Barberry, Goldthread)- is a potent antioxidant and anti-inflammatory known to protect against glutamate. Heads up it also lowers*** blood sugar and can help with fatty liver and SIBO “Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478787/ “Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067215

Lowering Glutamate | Berberine Containing Herbs2024-08-24T18:30:55-04:00

Snacks

I feel like I need to include every sort of disclaimer here because some of these foods are not perfect, and I am sure many will find reasons to criticize them. However, I will absolutely admit how hard it can be to switch your family to a whole food-based diet when coming from the standard American diet. While some of these foods are not ideal and can be very inflammatory due to poor quality oils, sugar, non-organic, high in x,y,z, etc., they may help reduce free glutamate exposure or are slightly cleaner [...]

Snacks2023-05-18T14:05:22-04:00

MEAL ACCOUTREMENTS

I feel like I need to include every sort of disclaimer here because some of these foods are not perfect, and I am sure many will find reasons to criticize them. However, I will absolutely admit how hard it can be to switch your family to a whole food-based diet when coming from the standard American diet. While some of these foods are not ideal and can be very inflammatory due to poor quality oils, sugar, non-organic, high in x,y,z, etc., they may help reduce free glutamate exposure or are slightly cleaner options when switching to [...]

MEAL ACCOUTREMENTS2023-05-02T10:37:58-04:00

Lowering Glutamate | Beta-caryophyllene, Copaiba, Cannabis, CBD

Beta-caryophyllene (found in Cannabis, Copaiba Essential Oil, etc) and CBD-  Protects against glutamate. “β-Caryophyllene Protects The C6 Glioma Cells Against Glutamate-Induced Excitotoxicity Through The Nrf2 Pathway.. Available from: https://www.researchgate.net/publication/265393128_b Caryophyllene_Protects_The_C6_Glioma_Cells_Against_Glutamate-Induced_Excitotoxicity_Through_The_Nrf2_Pathway [accessed Oct 26 2017].” https://www.researchgate.net/publication/265393128_b-Caryophyllene_Protects_The_C6_Glioma_Cells_Against_Glutamate-Induced_Excitotoxicity_Through_The_Nrf2_Pathway "Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271072/ Cannabis “Limited research carried out in humans tends to support the evidence that chronic cannabis use reduces levels of glutamate-derived metabolites in both cortical and subcortical brain areas. Research in animals tends to consistently suggest that Δ9-THC depresses glutamate synaptic transmission via CB1 receptor activation, affecting glutamate [...]

Lowering Glutamate | Beta-caryophyllene, Copaiba, Cannabis, CBD2024-08-24T18:32:15-04:00

Lowering Glutamate | Bee Pollen

Update: I've had several questions as to where we've sourced our bee pollen.  While we have historically purchased ours from our local health food store, here is a link for a great organic Amazon option, Greenbow Organic Bee Pollen. Bee Pollen-  There has been a recent article out indicating the neuroprotective benefits of bee pollen on excess glutamate. The article shows that bee pollen effectively reduced the neurotoxic effects of methylmercury by improving neurotransmitter defects, inflammation, apoptosis, and glutamate excitotoxicity.  This study also confirms that mice treated with methylmercury exhibited increased levels of glutamate and low [...]

Lowering Glutamate | Bee Pollen2024-08-24T18:30:19-04:00

Lowering Glutamate | Apigenin Flavonoid

Apigenin flavonoid- Found in chamomile, parsley, celery, thyme, lemon balm, cloves, etc.) After years of homeopathy, we discovered that the best remedy during a “flare” or times that we may be a little off, was a low dose of the homeopathic remedy, chamomilla.  So I decided to do a little research and of course discovered that it inhibits glutamate because of its high concentration of the flavonoid, apigenin. “The flavonoid inhibited also peak amplitude and frequency of spontaneous postsynaptic excitatory currents (sEPSCs). Finally, apigenin is neuroprotective against glutamate-induced neurotoxicity in cerebellar and cortical neurons in culture. Our [...]

Lowering Glutamate | Apigenin Flavonoid2024-08-24T18:21:13-04:00

Lowering Glutamate | Andrographis

Andrographis (andrographolide)–Most commonly known as popular herb to treat Lyme, but it is also has antiviral, antibacterial, and antiparasitic properties. Most importantly, andrographis inhibits microglial activation (see below).  We have sourced ours from Sage Woman Consulting & Apothecary : Tincture & Leaf/Flower “Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia” “Andrographolide exhibited neuroprotective effects, with accompanying suppression of NF-κB and microglial activation, and reduction in the production of cytokines including TNF-α and IL-1β, and pro-inflammatory factors such as PGE2. Our findings suggest that andrographolide may have therapeutic value in the treatment of [...]

Lowering Glutamate | Andrographis2024-08-24T18:23:11-04:00

Lowering Glutamate | Alpha Lipoic Acid

Alpha Lipoic Acid–  (found in low amounts in spinach, broccoli, yams, etc) ALA is most commonly known a chelating supplement as part of the Andy Cutler Protocol, it is also antioxidant that helps glutamate transport proteins, which aid in the removal of excess extracellular glutamate “Another particularly destructive product is 4-hydroxynonenal (4-HNE), an aldehydic lipid peroxidation product found in abundant supply in cases of neurodegeneration. Interestingly, peroxylnitrite and 4-HNE are found in the same neurons. This lipid peroxidation product has been shown to be especially destructive of synaptic connections and mitochondrial enzymes and can significantly inhibit [...]

Lowering Glutamate | Alpha Lipoic Acid2024-08-24T18:22:42-04:00
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DISCLAIMER
This website was created to share our journey with natural remedies, homeopathy, and by following a reduced excitatory inflammatory diet (REID). The information shared within this site has been gathered by a mother, not a physician, and should not act as medical advice. Nourished Blessings assumes no responsibility for anyone's use of information provided by a Nourished Blessings employee or consultant. Nourished Blessings does not represent that its advice will treat or cure any specific health issues. In consideration of the services of Nourished Blessings, under no circumstances shall Nourished Blessings be responsible for damages arising from use of the information provided, whether in contract or tort (including negligence or otherwise).
Please visit Unblind My Mind for more information on REID

I am a clinician that also engages in research. I work alongside HOHM Foundation Office of Research. All research conducted by HOHM Foundation Office of Research involving human subjects is undertaken according to human research protocols and is formally approved by the Canadian College of Naturopathic Medicine’s Research Ethics Board. Clients/patients may consent to have the anonymized clinical information from their case used for research purposes. I protect clients’/patients’ rights to privacy by withholding names and all other identifying information. Clients/patients have the right to give or withdraw consent to have case information used for research purposes at any time. By consenting, clients/patients do not waive any rights to legal recourse in the event of research-related harm (TCPS2-2022, article 3.2 (k)). If you have any inquiries about this research or would like to withdraw your consent, please contact HOHM Foundation Office of Research at [email protected].


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