Lowering Glutamate

Lowering Glutamate | Chinese Skullcap (Scutellaria Baicalensis)

Lowering Glutamate | Chinese Skullcap (Scutellaria Baicalensis)

Chinese Skullcap (Scutellaria Baicalensis)– neuroprotective against glutamate damage/metabolizes glutamate. “Thus, S.B. extract exhibited neuroprotection against excitotoxic cell death, and this neuroprotection was mediated through the inhibition of NMDA receptor function by interacting with the glycine binding site of the NMDA receptor.” https://www.hindawi.com/journals/tswj/2014/459549/ “Baicalein, a Constituent of Scutellaria baicalensis, Reduces Glutamate Release and Protects Neuronal Cell Against Kainic Acid-Induced Excitotoxicity in Rats” “This study is the first to demonstrate that the natural compound baicalein inhibits glutamate release from hippocampal nerve terminals, and executes a protective action against kainic acid-induced excitotoxicity in vivo. The findings enhance the understanding of [...]

Lowering Glutamate | Chinese Skullcap (Scutellaria Baicalensis)andistowe2024-08-24T18:35:13-04:00

Lowering Glutamate | Chinese Club Moss

Lowering Glutamate | Chinese Club Moss

Chinese Club Moss (Lycopodii Serrati) of the lycopodium family (for those homeopathy followers)– Neuroprotective by blocking the NMDA (a type of glutamate receptor) channels. Only Chinese Club Moss contains Huperzine A which is most commonly known to help with Alzheimers and memory loss. “Thus, on the one hand, HUP-A could be used as a pretreatment against OPs and it might also be a valuable therapeutic intervention in a variety of acute and chronic disorders by protecting against overstimulation of the excitatory amino acid pathway. By blocking NMDA ion channels without psychotomimetic side-effects, HUP-A may protect against [...]

Lowering Glutamate | Chinese Club Mossandistowe2024-08-24T18:34:42-04:00

Lowering Glutamate | Cat’s Claw (uncaria tomentosa)

Lowering Glutamate | Cat’s Claw (uncaria tomentosa)

Cat’s Claw (uncaria tomentosa)- NMDA (a type of glutamate receptor) inhibitor. Should be used with caution as it is a immune system activator and may be problematic for some. “Rhynchophylline and isorhynchophylline are major tetracyclic oxindole alkaloid components of Uncaira species, which have been long used as medicinal plants. In this study, the effects of rhynchophylline and isorhynchophylline on the ionotropic and metabotropic glutamatereceptor-mediated current responses were examined using Xenopus oocytes injected with total RNA prepared from rat cortices or cerebelli.” “hese results suggest that rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncairaspecies [...]

Lowering Glutamate | Cat’s Claw (uncaria tomentosa)andistowe2024-08-24T18:33:49-04:00

Lowering Glutamate | Black Cumin Seed

Lowering Glutamate | Black Cumin Seed

Black Cumin Seed (Nigella Sativa)– We have chosen to use black cumin seed oil to help lower glutamate levels. I have it linked in our medicine cabinet. “The secretion of different amino acids was studied in primary cultured cortical neurons by high-performance liquid chromatography (HPLC) using a derivation before injection with dansyl chloride. NS modulated amino acid release in cultured neurons; GABA was significantly increased whereas secretion of glutamate, aspartate, and glycine were decreased. The in vitro findings support the hypothesis that the sedative and depressive effects of NS observed in vivocould be based on changes of inhibitory/excitatory amino acids [...]

Lowering Glutamate | Black Cumin Seedandistowe2024-08-24T18:33:12-04:00

Lowering Glutamate | Bergamot Essential Oil

Lowering Glutamate | Bergamot Essential Oil

Bergamot Essential Oil– Neuroprotective and prevents glutamate accumulation “Prevention of Glutamate Accumulation and Upregulation of Phospho-Akt may Account for Neuroprotection Afforded by Bergamot Essential Oil against Brain Injury Induced by Focal Cerebral Ischemia in Rat.” https://www.ncbi.nlm.nih.gov/pubmed/19607983 Bergamot EO possesses a bitter aromatic taste and a characteristic pleasant aroma. It is a popular pharmacopoeias in many countries. It has been also reported for its hypolipemic and hypoglycemics activities, anti-inflammatory, and anti-cancer properties [66,67,68,69,70]. In folk medicine in many countries, it has been popularly used for fever and parasitic diseases. Due to its significant antimicrobial properties, it has been found [...]

Lowering Glutamate | Bergamot Essential Oilandistowe2024-08-24T18:31:32-04:00

Lowering Glutamate | Berberine Containing Herbs

Lowering Glutamate | Berberine Containing Herbs

Berberine (Alkaloid) Containing Herbs (Goldenseal, Barberry, Goldthread)- is a potent antioxidant and anti-inflammatory known to protect against glutamate. Heads up it also lowers*** blood sugar and can help with fatty liver and SIBO “Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478787/ “Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067215

Lowering Glutamate | Berberine Containing Herbsandistowe2024-08-24T18:30:55-04:00

Lowering Glutamate | Beta-caryophyllene, Copaiba, Cannabis, CBD

Lowering Glutamate | Beta-caryophyllene, Copaiba, Cannabis, CBD

Beta-caryophyllene (found in Cannabis, Copaiba Essential Oil, etc) and CBD- Protects against glutamate. “β-Caryophyllene Protects The C6 Glioma Cells Against Glutamate-Induced Excitotoxicity Through The Nrf2 Pathway.. Available from: https://www.researchgate.net/publication/265393128_b Caryophyllene_Protects_The_C6_Glioma_Cells_Against_Glutamate-Induced_Excitotoxicity_Through_The_Nrf2_Pathway [accessed Oct 26 2017].” https://www.researchgate.net/publication/265393128_b-Caryophyllene_Protects_The_C6_Glioma_Cells_Against_Glutamate-Induced_Excitotoxicity_Through_The_Nrf2_Pathway "Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271072/ Cannabis “Limited research carried out in humans tends to support the evidence that chronic cannabis use reduces levels of glutamate-derived metabolites in both cortical and subcortical brain areas. Research in animals tends to consistently suggest that Δ9-THC depresses glutamate synaptic transmission via CB1 receptor activation, affecting glutamate [...]

Lowering Glutamate | Beta-caryophyllene, Copaiba, Cannabis, CBDandistowe2024-08-24T18:32:15-04:00

Lowering Glutamate | Bee Pollen

Lowering Glutamate | Bee Pollen

Update: I've had several questions as to where we've sourced our bee pollen. While we have historically purchased ours from our local health food store, here is a link for a great organic Amazon option, Greenbow Organic Bee Pollen. Bee Pollen- There has been a recent article out indicating the neuroprotective benefits of bee pollen on excess glutamate. The article shows that bee pollen effectively reduced the neurotoxic effects of methylmercury by improving neurotransmitter defects, inflammation, apoptosis, and glutamate excitotoxicity. This study also confirms that mice treated with methylmercury exhibited increased levels of glutamate and low [...]

Lowering Glutamate | Bee Pollenandistowe2024-08-24T18:30:19-04:00

Lowering Glutamate | Apigenin Flavonoid

Lowering Glutamate | Apigenin Flavonoid

Apigenin flavonoid- Found in chamomile, parsley, celery, thyme, lemon balm, cloves, etc.) After years of homeopathy, we discovered that the best remedy during a “flare” or times that we may be a little off, was a low dose of the homeopathic remedy, chamomilla. So I decided to do a little research and of course discovered that it inhibits glutamate because of its high concentration of the flavonoid, apigenin. “The flavonoid inhibited also peak amplitude and frequency of spontaneous postsynaptic excitatory currents (sEPSCs). Finally, apigenin is neuroprotective against glutamate-induced neurotoxicity in cerebellar and cortical neurons in culture. Our [...]

Lowering Glutamate | Apigenin Flavonoidandistowe2024-08-24T18:21:13-04:00

Lowering Glutamate | Andrographis

Lowering Glutamate | Andrographis

Andrographis (andrographolide)–Most commonly known as popular herb to treat Lyme, but it is also has antiviral, antibacterial, and antiparasitic properties. Most importantly, andrographis inhibits microglial activation (see below). We have sourced ours from Sage Woman Consulting & Apothecary : Tincture & Leaf/Flower “Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia” “Andrographolide exhibited neuroprotective effects, with accompanying suppression of NF-κB and microglial activation, and reduction in the production of cytokines including TNF-α and IL-1β, and pro-inflammatory factors such as PGE2. Our findings suggest that andrographolide may have therapeutic value in the treatment of [...]

Lowering Glutamate | Andrographisandistowe2024-08-24T18:23:11-04:00